Evidence map›Paper›PMID 37122061›Full record

ArticlePediatrics2023

Respiratory Outcomes for Ventilator-Dependent Children With Bronchopulmonary Dysplasia.

Winston M Manimtim, Amit Agarwal, Stamatia Alexiou, Jonathan C Levin, Brianna Aoyama, Eric D Austin, Manvi Bansal, Sarah E Bauer, A Ioana Cristea, Julie L Fierro and 18 more

Open access · greenAbstract read
In one paragraph

Article in Pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 31 citations in OpenAlex.

  1. [Twelve-month clinical follow-up of patients diagnosed with bronchopulmonary dysplasia].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Observational
  2. Article
  3. Article
  4. Do systemic steroids impact survival free of cerebral palsy in preterm infants at risk for bronchopulmonary dysplasia?Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Tracheostomy Outcomes in Children With Bronchopulmonary Dysplasia.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Assessing the role of tracheostomy placement in bronchopulmonary dysplasia with pulmonary hypertension.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 1 country.

Winston M ManimtimDivision of Neonatology, Children's Mercy-Kansas City and University of Missouri Kansas City School of Medicine, Kansas City, Missouri.
Amit AgarwalDivision of Pulmonary Medicine, Arkansas Children's Hospital and University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Stamatia AlexiouDivision of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania.
Jonathan C LevinDivision of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Brianna AoyamaEudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland.
Eric D AustinPulmonary Medicine, Vanderbilt University and Vanderbilt University Medical Center, Nashville, Tennessee.
Manvi BansalPulmonology and Sleep Medicine, Children's Hospital of Los Angeles, Los Angeles, California.
Sarah E BauerDivision of Pediatric Pulmonology, Allergy and Sleep Medicine, Riley Children's Hospital and Indiana University, Indianapolis, Indiana.
A Ioana CristeaDivision of Pediatric Pulmonology, Allergy and Sleep Medicine, Riley Children's Hospital and Indiana University, Indianapolis, Indiana.
Julie L FierroDivision of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania.
Donna M GareyDepartment of Pediatrics, Creighton University School of Medicine, Phoenix Regional Campus, Phoenix, Arizona.
Lystra P HaydenDivision of Pulmonary Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Jacob A KaslowPulmonary Medicine, Vanderbilt University and Vanderbilt University Medical Center, Nashville, Tennessee.
Audrey N MillerDivision of Neonatology, Nationwide Children's Hospital and Ohio State University, Columbus, Ohio.
Paul E MoorePulmonology and Sleep Medicine, Children's Hospital of Los Angeles, Los Angeles, California.
Leif D NelinDivision of Neonatology, Nationwide Children's Hospital and Ohio State University, Columbus, Ohio.
Antonia P PopovaPediatric Pulmonology, University of Michigan, Ann Arbor, Michigan.
Jessica L RiceDivision of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania.
Michael C TracyDivision of Pediatric Pulmonary, Asthma and Sleep Medicine, Stanford University, Stanford, California.
Christopher D BakerSection of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Sara K DawsonDepartment of Pediatrics, Medical College of Wisconsin Milwaukee, Wisconsin.
Laurie C EldredgeDivision of Pediatric Pulmonary and Sleep Medicine, University of Washington, Seattle, Washington.
Khanh LaiDivision of Pediatric Pulmonary and Sleep Medicine, University of Utah, Salt Lake City, Utah.
Lawrence M RheinNeonatal-Perinatal Medicine/Pediatric Pulmonology, University of Massachusetts, Worcester, Massachusetts.
Roopa SiddaiahPediatric Pulmonology, Penn State Health, Hershey Pennsylvania.
Natalie VillafrancoPulmonary Medicine, Texas Children's Hospital and Baylor University, Houston, Texas.
Sharon A McGrath-MorrowDivision of Pulmonary Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania.
Joseph M CollacoEudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland.
Children's Hospital of Philadelphia · USChildren's Hospital of Los Angeles · USJohns Hopkins University · USNationwide Children's Hospital · USVanderbilt University Medical Center · USArkansas Children's Hospital · USBoston Children's Hospital · USCreighton University · USHarvard University · USIndiana University – Purdue University Indianapolis · USMedical College of Wisconsin · USPenn State Milton S. Hershey Medical Center · USRiley Hospital for Children · USStanford University · USTexas Children's Hospital · USUniversity of Colorado Denver · USUniversity of Massachusetts Chan Medical School · USUniversity of Michigan–Ann Arbor · USUniversity of Missouri–Kansas City · USUniversity of Utah · US

Funding

Resolution of Diffuse Inflammatory Lung Injury in Neonatal MiceR01HL114800 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MCGRATH-MORROW, SHARON ANN · 2013 to 2021
$3.3M
Genetic Epidemiology of Respiratory Function in Former Preterm ChildrenK23HL136851 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HAYDEN, LYSTRA P. · 2018 to 2022
$969k
Effect of Indoor Fine Particulate Matter Exposure on Respiratory Health Outcomes in Premature InfantsK23ES029985 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI RICE, JESSICA LYNNE · 2019 to 2022
$834k
The role of IL-33 in hyperoxia-induced neonatal lung injury and bronchopulmonary dysplasiaK08HL140104 · NHLBI · UNIVERSITY OF WASHINGTON · PI ELDREDGE, LAURIE CHRISTINE · 2020 to 2024
$804k
NHLBI NIH HHS K08 HL140104NHLBI NIH HHS K23 HL136851NHLBI NIH HHS R01 HL114800NIEHS NIH HHS K23 ES029985
6 · The paper itself

Abstract

objectivesTo describe outpatient respiratory outcomes and center-level variability among children with severe bronchopulmonary dysplasia (BPD) who require tracheostomy and long-term mechanical ventilation.

methodsRetrospective cohort of subjects with severe BPD, born between 2016 and 2021, who received tracheostomy and were discharged on home ventilator support from 12 tertiary care centers participating in the BPD Collaborative Outpatient Registry. Timing of key respiratory events including time to tracheostomy placement, initial hospital discharge, first outpatient clinic visit, liberation from the ventilator, and decannulation were assessed using Kaplan-Meier analysis. Differences between centers for the timing of events were assessed via log-rank tests.

resultsThere were 155 patients who met inclusion criteria. Median age at the time of the study was 32 months. The median age of tracheostomy placement was 5 months (48 weeks' postmenstrual age). The median ages of hospital discharge and first respiratory clinic visit were 10 months and 11 months of age, respectively. During the study period, 64% of the subjects were liberated from the ventilator at a median age of 27 months and 32% were decannulated at a median age of 49 months. The median ages for all key events differed significantly by center (P ≤ .001 for all events).

conclusionsThere is wide variability in the outpatient respiratory outcomes of ventilator-dependent infants and children with severe BPD. Further studies are needed to identify the factors that contribute to variability in practice among the different BPD outpatient centers, which may include inpatient practices.

Indexed as

Bronchopulmonary DysplasiaChildChild, PreschoolHumansInfantInfant, NewbornRespiration, ArtificialRetrospective StudiesTracheostomyVentilators, Mechanical

Identifiers

PMID37122061
PMCPMC10158083
OpenAlexW4367052423

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.