Evidence map›Paper›PMID 37121862›Full record

ReviewTrends in parasitology2023

The role of long noncoding RNAs in malaria parasites.

Trevor A Thompson, Zeinab Chahine, Karine G Le Roch

Open access · greenAbstract readReview
In one paragraph

Review in Trends in parasitology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The essential genome ofScience (New York, N.Y.) · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses.International journal of molecular sciences · 2024
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Trevor A ThompsonDepartment of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA.
Zeinab ChahineDepartment of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA.
Karine G Le RochDepartment of Molecular, Cell and Systems Biology, University of California Riverside, CA, USA. Electronic address: karine.leroch@ucr.edu.
University of California, Riverside · US

Funding

Chromatin structure and control of gene expression in the human malaria parasiteR01AI136511 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2018 to 2022
$3.4M
RAPs-mediated post-transcriptional control in Apicomplexan parasitesR01AI142743 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2018 to 2022
$2.8M
The spatial organization of the Plasmodium genome throughout its infectious cycleR01AI106775 · NIAID · UNIVERSITY OF WASHINGTON · PI LE ROCH, KARINE GAELLE, NOBLE, WILLIAM STAFFORD · 2013 to 2016
$1.8M
Evolution of the 3D chromatin structure in apicomplexan parasitesR21AI142506 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2019 to 2020
$479k
NIAID NIH HHS R01 AI106775NIAID NIH HHS R01 AI136511NIAID NIH HHS R01 AI142743NIAID NIH HHS R21 AI142506
6 · The paper itself

Abstract

The human malaria parasites, including Plasmodium falciparum, persist as a major cause of global morbidity and mortality. The recent stalling of progress toward malaria elimination substantiates a need for novel interventions. Controlled gene expression is central to the parasite's numerous life cycle transformations and adaptation. With few specific transcription factors (TFs) identified, crucial roles for chromatin states and epigenetics in parasite transcription have become evident. Although many chromatin-modifying enzymes are known, less is known about which factors mediate their impacts on transcriptional variation. Like those of higher eukaryotes, long noncoding RNAs (lncRNAs) have recently been shown to have integral roles in parasite gene regulation. This review aims to summarize recent developments and key findings on the role of lncRNAs in P. falciparum.

Indexed as

MalariaMalaria, FalciparumParasitesRNA, Long NoncodingAnimalsChromatinGene Expression RegulationHumansPlasmodium falciparumChromatinRNA, Long Noncodingchromatin structureepigeneticsgene regulationlncRNAsmalariaPlasmodium

Identifiers

PMID37121862
PMCPMC11695068
OpenAlexW4367396112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.