Evidence map›Paper›PMID 37121750›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Hepatitis C Virus-associated Cryoglobulinemic Livedo Reticularis Improved with Direct-acting Antivirals.

Keiji Yokoyama, Tomohiro Kino, Takahiro Nagata, Takashi Miyayama, Kumiko Shibata, Hiromi Fukuda, Ryo Yamauchi, Atsushi Fukunaga, Kaoru Umeda, Kazuhide Takata and 5 more

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Antibiotics for Rheumatologic Diseases: A Critical Review.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Keiji YokoyamaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Tomohiro KinoDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Takahiro NagataDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Takashi MiyayamaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Kumiko ShibataDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Hiromi FukudaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Ryo YamauchiDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Atsushi FukunagaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Kaoru UmedaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Kazuhide TakataDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Takashi TanakaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Satoshi ShakadoDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Shotaro SakisakaDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Shinichi ImafukuDepartment of Dermatology, Fukuoka University Faculty of Medicine, Japan.
Fumihito HiraiDepartment of Gastroenterology and Medicine, Fukuoka University Faculty of Medicine, Japan.
Fukuoka University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a case of hepatitis C virus (HCV)-associated cryoglobulinemic livedo reticularis in a woman in her 60s that improved with direct-acting antivirals (DAAs). Hyperpigmentation was observed in both lower legs, and a skin biopsy confirmed livedo reticularis, suggesting a relationship with cryoglobulinemia and HCV infection. DAAs with an NS5A inhibitor+NS3/4A protease inhibitor (glecaprevir/pibrentasvir) were administered for eight weeks, and a sustained virological response (SVR) was obtained. The disappearance of serum cryoglobulin was confirmed approximately two years after an SVR was obtained and livedo reticularis was improved. DAA therapy can be an effective therapeutic option for extrahepatic complications associated with HCV infection.

Indexed as

CryoglobulinemiaHepatitis CHepatitis C, ChronicLivedo ReticularisAntiviral AgentsFemaleHepacivirusHumansAntiviral Agentscryoglobulindirect-acting antivirals (DAAs)hepatitis C viruslivedo reticularis

Identifiers

PMID37121750
PMCPMC10781547
OpenAlexW4367281953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.