Evidence map›Paper›PMID 37121611›Full record

ReviewOtolaryngologic clinics of North America2023

Updates on Tumor Biology in Vestibular Schwannoma.

Aida Nourbakhsh, Christine T Dinh

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Otolaryngologic clinics of North America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Aida NourbakhshDepartment of Otolaryngology, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Suite 579, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, 1475 Northwest 12th Avenue, Miami, FL 33136, USA.
Christine T DinhDepartment of Otolaryngology, University of Miami Miller School of Medicine, 1120 Northwest 14th Street, Suite 579, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, 1475 Northwest 12th Avenue, Miami, FL 33136, USA. Electronic address: ctdinh@med.miami.edu.
University of Miami · US

Funding

Preclinical Testing of PI3K Inhibitors for Vestibular SchwannomasR01DC017264 · NIDCD · UNIVERSITY OF CENTRAL FLORIDA · PI FERNANDEZ-VALLE, CRISTINA MARIA, LIU, XUE Z · 2018 to 2022
$3.1M
Tumor-Mediated Hearing Loss in Neurofibromatosis Type IIK08DC017508 · NIDCD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DINH, CHRISTINE THUYVAN · 2019 to 2023
$840k
NIDCD NIH HHS K08 DC017508NIDCD NIH HHS R01 DC017264
6 · The paper itself

Abstract

Vestibular schwannomas (VSs) are benign tumors that develop after biallelic inactivation of the neurofibromatosis type 2 (NF2) gene that encodes the tumor suppressor merlin. Merlin inactivation leads to cell proliferation by dysregulation of receptor tyrosine kinase signaling and other intracellular pathways. In VS without NF2 mutations, dysregulation of non-NF2 genes can promote pathways favoring cell proliferation and tumorigenesis. The tumor microenvironment of VS consists of multiple cell types that influence VS tumor biology through complex intercellular networking and communications.

Indexed as

Neurofibromatosis 2Neuroma, AcousticBiologyGenes, Neurofibromatosis 2HumansNeurofibromin 2Signal TransductionTumor MicroenvironmentNeurofibromin 2MerlinNF2Tumor biologyTumor microenvironmentVestibular schwannoma

Identifiers

PMID37121611
PMCPMC12009539
OpenAlexW4367301438

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.