Evidence map›Paper›PMID 37121558›Full record

ArticleBone2023

High cardiorespiratory disease burden following a fracture among adults with intellectual disabilities.

Daniel G Whitney, Tao Xu, Daniel Whibley, Steven R Erickson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Daniel G WhitneyDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, USA; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, USA. Electronic address: dgwhit@umich.edu.
Tao XuKidney Epidemiology and Cost Center, School of Public Health, University of Michigan, Ann Arbor, USA.
Daniel WhibleyDepartment of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, USA; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, USA.
Steven R EricksonDepartment of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, USA.
University of Michigan–Ann Arbor · US

Funding

Addressing knowledge gaps by multi-level research design to optimize clinical trial development in order to reduce fracture burden for adults with neurodevelopmental disabilitiesR01AR076994 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HURVITZ, EDWARD A · 2021 to 2023
$616k
NIAMS NIH HHS R01 AR076994
6 · The paper itself

Abstract

backgroundAdults with intellectual disabilities have a greater risk for fragility fractures that begin to accumulate early in the adult lifespan, which may contribute to accelerated health declines. The objective was to determine if fragility fractures were associated with an increased 2-year rate of cardiorespiratory diseases among adults with intellectual disabilities.

methodThis retrospective cohort study used nationwide administrative claims data from 01/01/2011-12/31/2016 from the Medicare fee-for-service database. 2-year incidence of cardiorespiratory diseases were compared between adults ≥18 years old with intellectual disabilities with (n = 6183) vs. without (n = 67,842) an incident fragility fracture after confounder adjustment using Cox regression.

resultsFracture at the vertebral column, hip, non-proximal femur, tibia/fibula, and multiple sites had an elevated hazard ratio (HR) compared to those with no fracture for pneumonia, respiratory failure, heart failure, and cerebrovascular disease (HR range, 1.15-2.09, all P < 0.05), while humerus and radius/ulna fracture were associated with an elevated HR for congestive heart failure and cerebrovascular disease (HR range, 1.38-1.72, all P < 0.05).

conclusionsFragility fractures were associated with an increased incidence of cardiorespiratory diseases among adults with intellectual disabilities.

Indexed as

Intellectual DisabilityOsteoporotic FracturesRadius FracturesAdolescentAdultAgedHumansIncidenceMedicareProportional Hazards ModelsRetrospective StudiesRisk FactorsUnited StatesCardiorespiratory diseaseFractureIntellectual disabilities

Identifiers

PMID37121558
PMCPMC10360920
OpenAlexW4367301043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.