Evidence map›Paper›PMID 37121493›Full record

ArticleInternational journal of pharmaceutics2023

Sequential Flash NanoPrecipitation for the scalable formulation of stable core-shell nanoparticles with core loadings up to 90.

Nicholas J Caggiano, Satya K Nayagam, Leon Z Wang, Brian K Wilson, Parker Lewis, Shadman Jahangir, Rodney D Priestley, Robert K Prud'homme, Kurt D Ristroph

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicholas J CaggianoDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Satya K NayagamDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Leon Z WangDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Brian K WilsonDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Parker LewisDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Shadman JahangirDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Rodney D PriestleyDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States; Princeton Materials Institute, Princeton University, Princeton, NJ 08544, United States.
Robert K Prud'hommeDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Kurt D RistrophDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States. Electronic address: ristroph@purdue.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flash NanoPrecipitation (FNP) is a scalable, single-step process that uses rapid mixing to prepare nanoparticles with a hydrophobic core and amphiphilic stabilizing shell. Because the two steps of particle self-assembly - (1) core nucleation and growth and (2) adsorption of a stabilizing polymer onto the growing core surface - occur simultaneously during FNP, nanoparticles formulated at core loadings above approximately 70% typically exhibit poor stability or do not form at all. Additionally, a fundamental limit on the concentration of total solids that can be introduced into the FNP process has been reported previously. These limits are believed to share a common mechanism: entrainment of the stabilizing polymer into the growing particle core, leading to destabilization and aggregation. Here, we demonstrate a variation of FNP which separates the nucleation and stabilization steps of particle formation into separate sequential mixers. This scheme allows the hydrophobic core to nucleate and grow in the first mixing chamber unimpeded by adsorption of the stabilizing polymer, which is later introduced to the growing nuclei in the second mixer. Using this Sequential Flash NanoPrecipitation (SNaP) technique, we formulate stable nanoparticles with up to 90% core loading by mass and at 6-fold higher total input solids concentrations than typically reported.

Indexed as

NanoparticlesPolymersHydrophobic and Hydrophilic InteractionsParticle SizePolymers

Identifiers

PMID37121493
PMCPMC10262063

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.