Evidence map›Paper›PMID 37121391›Full record

ArticleChest2023

High-Definition Videobronchoscopy for the Diagnosis of Airway Involvement in Sarcoidosis: The Enhance Sarcoidosis Multicenter Study.

Vanina Livi, Ilya Sivokozov, Jouke T Annema, Piero Candoli, Igor Vasilev, Tess Kramer, Marco Ferrari, Karan Madan, David Fielding, Septimiu Murgu and 5 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. A case of pulmonary and cutaneous sarcoidosis.Breathe (Sheffield, England) · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 7 countries.

Vanina LiviDivision of Interventional Pulmonology, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome.
Ilya SivokozovEndoscopy Department, Central TB Research Institute, Moscow, Russia.
Jouke T AnnemaDepartment of Respiratory Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
Piero CandoliInterventional Pulmonology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna.
Igor VasilevState Research Institute of Phtisiopulmonology, St. Petersburg, Russia.
Tess KramerDepartment of Respiratory Medicine, Amsterdam UMC, Amsterdam, The Netherlands.
Marco FerrariInterventional Pulmonology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna.
Karan MadanDepartment of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India.
David FieldingDepartment of Thoracic Medicine, The Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia; UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Septimiu MurguSection of Pulmonary and Critical Care Medicine/Interventional Pulmonology, The University of Chicago, Chicago, IL.
Alessandra CancellieriPathology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome.
Lyudmila A SemyonovaDepartment of Pathomorphology, Cell Biology and Biochemistry, Central TB Research Institute, Moscow, Russia.
Mariangela PuciClinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Giovanni SotgiuClinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Rocco TrisoliniDivision of Interventional Pulmonology, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome; Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Hearth, Rome. Electronic address: rocco.trisolini@policlinicogemelli.it.
Agostino Gemelli University Polyclinic · ITAmsterdam University Medical Centers · NLAzienda USL di Bologna · ITUniversity of Sassari · ITAll India Institute of Medical Sciences · INCentral Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences · RUInstitute of Molecular Pathology and Pathomorphology · RUSaint-Petersburg Research Institute of Phthisiopulmonology · RUThe University of Queensland · AUUniversità Cattolica del Sacro Cuore · ITUniversity of Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe ability of high-definition (HD) videobronchoscopy to detect airway involvement in sarcoidosis has not been evaluated previously. RESEARCH QUESTION: What is the role of HD videobronchoscopy in the identification of sarcoidosis-associated airway abnormalities (AAs)? What are the patterns of AAs more commonly observed and more frequently associated with the detection of granulomas in endobronchial biopsy (EBB)? STUDY DESIGN AND

methodsIn this prospective international multicenter cohort study, consecutive patients with suspected sarcoidosis underwent airway inspection with an HD videobronchoscope and EBB using a standardized workflow. AAs were classified according to six patterns defined a priori: nodularity, cobblestoning, thickening, plaque, increased vascularity, and miscellaneous. We assessed diagnostic yield of EBB, prevalence of AAs, and interobserver agreement for different patterns of AAs.

resultsAAs were identified in 64 of 134 patients with sarcoidosis (47.8%), with nodularity (n = 23 [17.2%]), plaque (n = 19 [14.2%]), and increased vascularity (n = 19 [14.2%]) being the most prevalent. The diagnostic yield of EBB was 36.6%. AAs were significantly more prevalent in patients with than in those without nonnecrotizing granulomas on EBB (67.4% vs 36.5%; P = .001). Likewise, parenchymal disease on CT scan imaging was significantly more common in patients with than in those without nonnecrotizing granulomas on EBB (79.6% vs 54.1%; P = .003). On a per-lesion analysis, nonnecrotizing granulomas were seen especially in EBB samples obtained from areas of cobblestoning (9/10 [90%]) and nodularity (17/29 [58.6%]). The overall diagnostic yield of random EBB was low (31/134 [23.1%]). The interobserver agreement for the different patterns of AA was fair (Fleiss κ = 0.34).

interpretationIn a population with a large prevalence of White Europeans, HD videobronchoscopy detected AAs in approximately one-half of patients with sarcoidosis. The diagnostic yield of EBB was higher in patients with parenchymal involvement on CT scan imaging and in those with AAs, especially if manifesting as cobblestoning and nodularity. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT4743596; URL: www. CLINICALTRIALS: gov.

Indexed as

SarcoidosisSarcoidosis, PulmonaryBronchoscopyCohort StudiesGranulomaHumansProspective StudiesCT scanendobronchial biopsyendobronchial ultrasoundgranulomahigh-definition videobronchoscopysarcoidosis

Identifiers

PMID37121391
PMCPMC10635836
OpenAlexW4367319239

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.