Evidence map›Paper›PMID 37121226›Full record

ArticleCerebrovascular diseases (Basel, Switzerland)2024

Association of Dental Infections with Intracranial Atherosclerotic Stenosis.

Souvik Sen, Jaclyn Meyer, Rachel Mascari, Tushar Trivedi, Fareed Suri, Bruce Wasserman, Wayne Rosamond, Kevin Moss, James Beck, Rebecca F Gottesman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebrovascular diseases (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Association between dental diseases and stroke.The Saudi dental journal · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Souvik SenDepartment of Neurology, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Jaclyn MeyerDepartment of Neurology, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Rachel MascariDepartment of Neurology, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Tushar TrivediDepartment of Neurology, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Fareed SuriDepartment of Neurology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
Bruce WassermanDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA.
Wayne RosamondDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kevin MossDivision of Oral and Craniofacial Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
James BeckDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Rebecca F GottesmanStroke Branch, National Institute of Neurological Disorders and Stroke Intramural Research Program, Bethesda, Maryland, USA.
University of South Carolina · USUniversity of North Carolina at Chapel Hill · USNational Institute of Neurological Disorders and Stroke · USUniversity of Maryland, Baltimore · USUniversity of Minnesota · US

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
PeRiodontal treatment to Eliminate Minority InEquality and Rural disparities in Stroke (PREMIERS)R01MD009738 · NIMHD · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SEN, SOUVIK · 2015 to 2019
$3.4M
The Intracranial Atherosclerotic Disease and Cognitive Impairment StudyR01HL105930 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SURI, MUHAMMAD FAREED, WASSERMAN, BRUCE A · 2011 to 2014
$2.7M
Training Program for the Next Generation of Oral Health Researchers (NextGen)T90DE021986 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EVERETT, ERIC T. · 2011 to 2017
$2.3M
GENOME-WIDE ASSOCIATION STUDY OF PERIODONTAL DISEASER01DE021418 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI OFFENBACHER, STEVEN · 2011 to 2012
$658k
NCATS NIH HHS UL1 TR001111NHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS R01 HL105930NIDCR NIH HHS R01 DE021418NIDCR NIH HHS R01 DE021986NIDCR NIH HHS T90 DE021986NIMHD NIH HHS R01 MD009738
6 · The paper itself

Abstract

introductionPeriodontal disease (PD) and dental caries are oral infections leading to tooth loss that are associated with atherosclerosis and cerebrovascular disease. We assessed the hypothesis that PD and caries are associated with asymptomatic intracranial atherosclerosis (ICAS) in the Atherosclerosis Risk in Communities (ARIC) study.

methodsFull-mouth clinical periodontal measurements (7 indices) collected at 6 sites per tooth from 6,155 subjects from the Dental Atherosclerosis Risk in Communities Study (DARIC) without prior stroke were used to differentiate seven PD stages (Periodontal Profile Class [PPC]-I to -VII) and dental caries on coronal dental surface (DS) and dental root surface (DRS). A stratified subset underwent 3D time-of-flight MR angiogram and 3D high isotropic-resolution black blood MRI. ICAS was graded according to the criteria established by the Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) trial. We evaluated the relationship between PD stage and dental caries with asymptomatic ICAS, graded as no ICAS, <50% ICAS, and ≥50% ICAS.

resultsAmong dentate subjects who underwent vascular imaging, 801 (70%) had no ICAS, 232 (20%) had <50% ICAS, and 112 (10%) had ≥50% ICAS. Compared to participants without gum disease (PPC-I), participants with mild-moderate tooth loss (PPC-VI), severe tooth loss (PPC-VII), and severe PD (PPC-IV) had higher odds of having <50% ICAS. Participants with extensive gingivitis (PPC-V) had significantly higher odds of having ≥50% ICAS. This association remained significant after adjusting for confounding variables: age, gender, race, hypertension, diabetes, dyslipidemia, 3-level education, and smoking status. There was no association between dental caries (DS and DRS) and ICAS <50% and ≥50%.

conclusionWe report significant associations between mild-moderate tooth loss, severe tooth loss, and severe PD with <50% ICAS as well as an association between extensive gingivitis and ≥50% ICAS. We did not find an association between dental caries and ICAS.

Indexed as

AtherosclerosisDental CariesGingivitisIntracranial ArteriosclerosisTooth LossConstriction, PathologicHumansRisk FactorsInflammationIntracranial atherosclerotic stenosisPeriodontal disease

Identifiers

PMID37121226
PMCPMC11832010
OpenAlexW4367303548

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.