Evidence map›Paper›PMID 37121130›Full record

ArticleBiochemical and biophysical research communications2023

Spotted fever rickettsia-induced microvascular endothelial barrier dysfunction is delayed by the calcium channel blocker benidipine.

Yuri Kim, Emily G Clemens, Jennifer M Farner, Andres Londono-Barbaran, Dennis J Grab, J Stephen Dumler

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuri KimHenry M. Jackson Foundation for the Advancement of Military Medicine, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA; Uniformed Services of the Health Sciences, Department of Pathology, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. Electronic address: yuri.kim.ctr@usuhs.edu.
Emily G ClemensUniformed Services of the Health Sciences, Department of Pathology, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. Electronic address: emily.clemens@usuhs.edu.
Jennifer M FarnerHenry M. Jackson Foundation for the Advancement of Military Medicine, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA; Uniformed Services of the Health Sciences, Department of Pathology, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. Electronic address: jennifer.farner.ctr@usuhs.edu.
Andres Londono-BarbaranHenry M. Jackson Foundation for the Advancement of Military Medicine, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA; Uniformed Services of the Health Sciences, Department of Pathology, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. Electronic address: andres.londono-barbaran.ctr@usuhs.edu.
Dennis J GrabUniformed Services of the Health Sciences, Department of Pathology, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. Electronic address: dennis.grab@usuhs.edu.
J Stephen DumlerUniformed Services of the Health Sciences, Department of Pathology, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA. Electronic address: john.dumler@usuhs.edu.
Henry M. Jackson Foundation · USUniformed Services University of the Health Sciences · US

Funding

Host Ca2+, actin, and ATP production in rickettsia-endothelial cell dysfunctionR21AI171791 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI DUMLER, JOHN STEPHEN · 2022 to 2023
$418k
NIAID NIH HHS R21 AI171791
6 · The paper itself

Abstract

The tick-borne bacterium Rickettsia parkeri is an obligate intracellular pathogen that belongs to spotted fever group rickettsia (SFGR). The SFG pathogens are characterized by their ability to infect and rapidly proliferate inside host vascular endothelial cells that eventually result in impairment of vascular endothelium barrier functions. Benidipine, a wide range dihydropyridine calcium channel blocker, is used to prevent and treat cardiovascular diseases. In this study, we tested whether benidipine has protective effects against rickettsia-induced microvascular endothelial cell barrier dysfunction in vitro. We utilized an in vitro vascular model consisting of transformed human brain microvascular endothelial cells (tHBMECs) and continuously monitored transendothelial electric resistance (TEER) across the cell monolayer. We found that during the late stages of infection when we observed TEER decrease and when there was a gradual increase of the cytoplasmic [Ca

Indexed as

DihydropyridinesRickettsiaSpotted Fever Group RickettsiosisVascular DiseasesCalcium Channel BlockersEndothelial CellsHumansNifedipinebenidipineCalcium Channel BlockersDihydropyridinesNifedipineBenidipineBrain microvascular endothelial cellsCalcium channel blockersElectric cell impedance sensingNifedipineSpotted fever group RickettsiaVascular permeability

Identifiers

PMID37121130
PMCPMC10362780
OpenAlexW4366824897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.