ArticleJournal of infection and public health2023
Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study.
Article in Journal of infection and public health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- The prevalence and etiology of anemia and the association between anemia and all-cause mortality: a cohort study over a 9-year period.BMC geriatrics · 2025Article
- Effects of missed anti-tuberculosis therapy doses on treatment outcome: a multi-center cohort study.Lancet regional health. Americas · 2025Article
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- Treatment outcomes of pulmonary TB in adults in Indonesia.IJTLD open · 2025Article
- Haematological markers as predictive tools for tuberculosis in PLHIV: a retrospective cohort study in Gujarat, India.BMC infectious diseases · 2025Article
- Development of a clinical prediction model for poor treatment outcomes in the intensive phase in patients with initial treatment of pulmonary tuberculosis.Frontiers in medicine · 2025Article
- Effectiveness and safety of modified fully oral 9-month treatment regimens for rifampicin-resistant tuberculosis: a prospective cohort study.The Lancet. Infectious diseases · 2024Observational
- Impact of pyrazinamide usage on serious adverse events in elderly tuberculosis patients: A multicenter cohort study.PloS one · 2024Article
- Coexistent anemia modulates systemic inflammation and exacerbates disease severity and adverse treatment outcomes in tuberculosis.Frontiers in tuberculosis · 2024Article
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Authors and funding
13 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundTuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity of anemia in PWTB prior to anti-TB treatment (ATT) was a risk factor for an unfavorable outcome.
methodsPatients ≥ 18 years old with culture-confirmed drug-susceptible pulmonary TB enrolled between 2015 and 2019 in a multi-center Brazilian cohort were followed for up to 24 months and classified according to anemia severity (mild, moderate, and severe), based on hemoglobin levels. A multinomial logistic regression model was employed to assess whether anemia was associated with unfavorable outcome (death, failure, loss to follow-up, regimen modification or relapse), compared to treatment success (cure or treatment completion).
resultsAmong 786 participants who met inclusion criteria, 441 (56 %) were anemic at baseline. Patients with moderate/severe anemia were more HIV-seropositive, as well as more symptomatic and had higher frequencies of unfavorable outcomes compared to the other groups. Moderate/severe anemia (adjusted OR [aOR]: 7.80, 95 %CI:1.34-45.4, p = 0.022) was associated with death independent of sex, age, BMI, HIV and glycemic status.
conclusionModerate/severe anemia prior to ATT was a significant risk factor for death. Such patients should be closely monitored given the high risk of unfavorable ATT outcomes.
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