Evidence map›Paper›PMID 37120921›Full record

ArticleDrug and alcohol dependence2023

Antecedents of fatal overdose in an adult cohort identified through administrative record linkage in Indiana, 2015-2022.

Bradley Ray, Kaitlyn Christian, Timothy Bailey, Madison Alton, Alison Proctor, John Haggerty, Evan Lowder, Matthew C Aalsma

Open access · hybridAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Observational
  4. Article
  5. Review
  6. Groundbreaking Research from NIDA Addressing the Challenges of the Opioid Epidemic.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Bradley RayRTI International, 3040 Cornwallis Road, Research Triangle Park, NC27709, United States. Electronic address: bradleyray@rti.org.
Kaitlyn ChristianIndiana Management Performance Hub, 100 North Senate Avenue, Room N855, Indianapolis, IN46204, United States.
Timothy BaileyIndiana Management Performance Hub, 100 North Senate Avenue, Room N855, Indianapolis, IN46204, United States.
Madison AltonIndiana Division of Mental Health and Addiction, 402 West Washington Street W353, Indiana, IN46204, United States.
Alison ProctorRTI International, 3040 Cornwallis Road, Research Triangle Park, NC27709, United States.
John HaggertyRTI International, 3040 Cornwallis Road, Research Triangle Park, NC27709, United States.
Evan LowderDepartment of Criminology, Law and Society, George Mason University, 4400 University Drive, 4F4, Fairfax, VA22030, United States.
Matthew C AalsmaDepartment of Pediatrics, Indiana University School of Medicine, 340 W. 10th StreetIndianapolisIN46202, United States.
RTI International · USGeorge Mason University · USIndiana University – Purdue University Indianapolis · US

Funding

Alliance to Disseminate Addiction Prevention and Treatment (ADAPT): A Statewide Learning Health System to Reduce Substance Use among Justice-Involved Youth in Rural Communities.UG1DA050070 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI AALSMA, MATTHEW · 2019 to 2023
$5.7M
Fatal Overdose Review Teams - Research to Enhance Surveillance Systems (FORTRESS)R33DA057660 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI AALSMA, MATTHEW, RAY, BRADLEY · 2024 to 2024
$3.3M
Fatal Overdose Review Teams - Research to Enhance Surveillance Systems (FORTRESS)R61DA057660 · NIDA · INDIANA UNIVERSITY INDIANAPOLIS · PI AALSMA, MATTHEW, RAY, BRADLEY · 2022 to 2022
$1.6M
NIDA NIH HHS R33 DA057660NIDA NIH HHS R61 DA057660NIDA NIH HHS UG1 DA050070
6 · The paper itself

Abstract

backgroundThe United States continues to experience unprecedented rates of overdose mortality and need to identify effective policies or practices that can be implemented. This study aims to measure the prevalence, frequency, timing, and rate of touchpoints that occurred prior to a fatal overdose where communities might intervene.

methodsIn collaboration with Indiana state government, we conducted record-linkage of statewide administrative datasets to vital records (January 1, 2015, through August 26, 2022) to identify touchpoints (jail booking, prison release, prescription medication dispensation, emergency department visits, and emergency medical services). We examined touchpoints within 12-months prior to a fatal overdose among an adult cohort and explored variation over time and by demographic characteristics.

resultsOver the 92-month study period there were 13,882 overdose deaths (89.3% accidental poisonings, X40-X44) in our adult cohort that were record-linked to multiple administrative datasets and revealed nearly two-thirds (64.7%; n=8980) experienced an emergency department visit, the most prevalent touchpoint followed by prescription medication dispensation, emergency medical services responses, jail booking, and prison release. However, with approximately 1 out of every 100 returning citizens dying from drug overdose within 12-months of release, prison release had the highest touchpoint rate followed by emergency medical services responses, jail booking, emergency department visits, and prescription medication dispensation.

conclusionRecord-linking administrative data from routine practice to vital records from overdose mortality is a viable means of identifying where resources should be situated to reduce fatal overdose, with potential to evaluate the effectiveness of overdose prevention efforts.

Indexed as

Drug OverdoseEmergency Medical ServicesPrescription DrugsAdultAnalgesics, OpioidEmergency Service, HospitalHumansIndianaPrisonsUnited StatesAnalgesics, OpioidPrescription DrugsEmergency departmentEmergency medical servicesIncarcerationNonfatal overdosePrescription opioid dispensation

Identifiers

PMID37120921
PMCPMC11343318
OpenAlexW4366752410

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.