ArticleEye (London, England)2023
Comparison of quantitative assessment and efficiency of diabetic retinopathy diagnosis using ETDRS seven-field imaging and two ultra-widefield imaging.
Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 9 citations in OpenAlex.
- Deep Learning Model to Detect Diabetic Retinopathy in 45° Images Using Ground Truth from Ultra-Widefield Imaging.Ophthalmology science · 2026Article
- Article
- A prospective comparison of ultrawide-field and two-field fundus imaging for diabetic retinopathy assessment.BMC medical imaging · 2026Observational
- Ultra-widefield color fundus photography in diabetic retinopathy: from panretinal assessment to multimodal integration.Frontiers in medicine · 2026Review
- Sensitivity and utility of ultra-wide field imaging for the detection of peripheral retinal breaks in a large Irish tertiary referral centre.Eye (London, England) · 2025Article
- Comparisons of Visibility of Two-Color (RG) to Three-Color (RGB) Ultra-Widefield Images for Ten Types of Fundus Lesions.Translational vision science & technology · 2025Article
- Comparison of a Novel Ultra-Widefield Three-Color Scanning Laser Ophthalmoscope to Other Retinal Imaging Modalities in Chorioretinal Lesion Imaging.Translational vision science & technology · 2025Article
- ETDRS grading with CLARUS ultra-widefield images shows agreement with 7-fields colour fundus photography.BMC ophthalmology · 2024Article
- The role of ultra-widefield imaging with navigated central and peripheral cross-sectional and three-dimensional swept source optical coherence tomography in ophthalmology: Clinical applications.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
- Comparison of Standard 7-Field, Clarus, and Optos Ultrawidefield Imaging Systems for Diabetic Retinopathy (COCO Study).Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study compared the efficiency of diabetic retinopathy (DR) diagnosis and differences in the relative visible retinal area among the Early Treatment Diabetic Retinopathy Study (ETDRS) seven-field, ultra-widefield (UWF)-Optos, and UWF-Clarus fundus imaging methods.
methodsThis was a prospective and clinic-based comparative study. All patients underwent three fundus examinations, and all images were graded using the ETDRS severity scale. We compared and analysed the agreement of DR severity and the relative visible retinal area among the three fundus examination methods, and the number and type of lesions outside the ETDRS seven-field (peripheral lesions) between the two UWF imaging methods.
resultsA total of 202 patients (386 eyes) were included. Weighted kappa for the agreement between ETDRS seven-field and blinded Optos images was 0.485; between ETDRS seven-field and blinded Clarus images, 0.924; and between blinded Optos and Clarus images, 0.461. Blinded Clarus showed excellent performance when a ETDRS scale was used for grading the images. The relative visible retinal area for ETDRS seven-field images was 195 ± 28 disc area (DA); single Optos images, 371 ± 69 DA; single Clarus images, 261 ± 65 DA; two-montage Clarus images, 462 ± 112 DA; and four-montage Clarus images, 598 ± 139 DA. The relative visible retinal area was statistically significant between any two of the imaging systems used. In total, 2015 and 4200 peripheral lesions were detected in single Optos and Clarus images, respectively (P < 0.001). These peripheral lesions on two UWF images suggested a more severe DR level in approximately 10% and 12% of eyes, respectively.
conclusionUWF-Clarus fundus imaging offers a suitable assessment approach for DR severity; it could improve DR diagnosis and has the potential to replace ETDRS seven-field imaging after additional clinical trials.
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