Evidence map›Paper›PMID 37120606›Full record

ArticleScientific reports2023

Bifurcation analysis of hepatitis B virus with non-cytolytic cure process on infected liver and blood cells.

Tesfaye Tefera Mamo

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Tesfaye Tefera MamoDepartement of Mathematics, College of Natural and Computational Science, Debre Berhan University, Post Code 445, Debre Berhan, Ethiopia. testef21@gmail.com.
Debre Berhan University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The phenomenon of bifurcation in disease transmission models has been observed in a number of epidemiological models. The consequence of bifurcation is that the classical requirement of the reproduction number being less than unity becomes only a necessary, but not sufficient, for disease elimination. This paper addresses the problem of finding the causes of bifurcation in standard deterministic models for the spread of HBV diseases with non-Cytolytic cure processes on infected liver and blood cells. The model contains logistic growth of healthy liver and blood cells and non -Cytolytic cure processes of infected cells. I have got that the model exhibits back ward and forward bifurcations with some conditions. The existence of a backward bifurcation is an interesting artifact since this means that the disease cannot be eradicated by simply reducing the value of the basic reproduction number [Formula: see text] below 1.This can have important implications on drug therapy protocols, since it sheds light on possible control mechanisms for disease eradication.

Indexed as

Hepatitis B virusModels, BiologicalBasic Reproduction NumberBlood CellsLiver

Identifiers

PMID37120606
PMCPMC10148853
OpenAlexW4367368194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.