Evidence map›Paper›PMID 37120576›Full record

ArticleArthritis research & therapy2023

Stiffness and axial pain are associated with the progression of calcification in a mouse model of diffuse idiopathic skeletal hyperostosis.

Dale E Fournier, Matthew A Veras, Courtney R Brooks, Diana Quinonez, Magali Millecamps, Laura S Stone, Cheryle A Séguin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dale E Fournier *Health and Rehabilitation Sciences (Physical Therapy), Faculty of Health Sciences, The University of Western Ontario, London, ON, N6A 5B9, Canada.
Matthew A Veras *Bone and Joint Institute, The University of Western Ontario, London, ON, N6A 5C1, Canada.
Courtney R BrooksDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, N6A 5C1, Canada.
Diana QuinonezDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON, N6A 5C1, Canada.
Magali MillecampsFaculty of Dentistry, McGill University, Montreal, QC, H3A 1G1, Canada.
Laura S StoneFaculty of Dentistry, McGill University, Montreal, QC, H3A 1G1, Canada.
Cheryle A SéguinBone and Joint Institute, The University of Western Ontario, London, ON, N6A 5C1, Canada. cheryle.seguin@schulich.uwo.ca.

Funding

CIHR MOP-115068
6 · The paper itself

Abstract

backgroundDiffuse idiopathic skeletal hyperostosis (DISH) is characterized by progressive calcification of spinal tissues; however, the impact of calcification on pain and function is poorly understood. This study examined the association between progressive ectopic spine calcification in mice lacking equilibrative nucleoside transporter 1 (ENT1

methodsA longitudinal study design was used to assess radiating pain, axial discomfort, and physical function in wild-type and ENT1

resultsIncreased spine calcification in ENT1

conclusionThese data suggest that ENT1

Indexed as

CalcinosisHyperostosis, Diffuse Idiopathic SkeletalAnimalsCalcitonin Gene-Related PeptideFemaleLongitudinal StudiesMaleMicePainSpineCalcitonin Gene-Related PeptideBehavioral measures of painDiffuse idiopathic skeletal hyperostosis (DISH)ENT1 knockoutLongitudinal analysisNeuroplastic changesPainPreclinical modelSpine mineralizationSpine stiffness

Identifiers

PMID37120576
PMCPMC10148510

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.