Evidence map›Paper›PMID 37120567›Full record

ArticleBMC anesthesiology2023

Trichloroethanol, an active metabolite of chloral hydrate, modulates tetrodotoxin-resistant Na

Gimin Kim, Hyunjung Kim, Il-Sung Jang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Gimin KimDepartment of Pediatric Dentistry, School of Dentistry, Kyungpook National University, Daegu, 41940, Republic of Korea.
Hyunjung KimDepartment of Pediatric Dentistry, School of Dentistry, Kyungpook National University, Daegu, 41940, Republic of Korea.
Il-Sung JangDepartment of Pharmacology, School of Dentistry, Kyungpook National University, 2177 Dalgubeol-daero, Jung-gu, Daegu, 41940, Republic of Korea. jis7619@knu.ac.kr.
Kyungpook National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChloral hydrate is a sedative-hypnotic drug widely used for relieving fear and anxiety in pediatric patients. However, mechanisms underlying the chloral hydrate-mediated analgesic action remain unexplored. Therefore, we investigated the effect of 2',2',2'-trichloroethanol (TCE), the active metabolite of chloral hydrate, on tetrodotoxin-resistant (TTX-R) Na

methodsThe TTX-R Na

resultsTrichloroethanol decreased the peak amplitude of transient TTX-R I

conclusionsOur findings suggest that chloral hydrate, through its active metabolite TCE, inhibits TTX-R I

Indexed as

NociceptorsSodium ChannelsAnimalsChloral HydrateEthylene ChlorohydrinGanglia, SpinalMembrane PotentialsRatsRats, Sprague-DawleyTetrodotoxin2,2,2-trichloroethanolChloral HydrateEthylene ChlorohydrinSodium ChannelsTetrodotoxinAnalgesiaChloral hydrateNociceptive neuronsPatch clampTrichloroethanolTTX-R Na+ channels

Identifiers

PMID37120567
PMCPMC10148498
OpenAlexW4367368717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.