ReviewWorld journal of surgical oncology2023
Prognostic analysis of 2-5 cm diameter gastric stromal tumors with exogenous or endogenous growth.
Review in World journal of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Retrospective comparison of precutting endoscopic band ligation and endoscopic submucosal dissection for small gastric muscularis propria tumors.World journal of gastrointestinal endoscopy · 2026Article
- Correlation of ultrasonic characteristics, clinicopathological features, and biological risk classification in gastric gastrointestinal stromal tumors and construction of a preoperative prediction model: a feasibility study.Quantitative imaging in medicine and surgery · 2026Article
- Postoperative perforation risk after endoscopic removal of gastric gastrointestinal stromal tumors: Development and validation of a predictive nomogram.World journal of gastrointestinal endoscopy · 2025Article
- Association between calcification and risk stratification in gastric gastrointestinal stromal tumors.Abdominal radiology (New York) · 2025Article
- Clinical characteristics and prognostic analysis of postoperative recurrence or metastasis of low-risk gastrointestinal stromal tumors.World journal of surgical oncology · 2024Article
- Risk factors of positive lymph node metastasis after radical gastrectomy for gastric cancer and construction of prediction models.American journal of cancer research · 2024Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere has been limited research on the prognosis differences in patients with gastric stromal tumor invasion of the plasma membrane surface. This study intended to investigate whether there is a difference in prognosis in patients with endogenous or exogenous 2-5 cm diameter GISTs.
methodsWe retrospectively analyzed the clinicopathological and follow-up data of gastric stromal tumor patients, all of whom underwent surgical resection for primary GIST at Nanjing Drum Tower Hospital from December 2010 to February 2022. We classified patients based on tumor growth patterns and then investigated the association between tumor growth patterns and clinical outcomes. Progression-free survival (PFS) and overall survival (OS) were calculated by the Kaplan‒Meier method.
resultsA total of 496 gastric stromal tumor patients were enrolled in this study, among which 276 patients had tumors of 2-5 cm in diameter. Of these 276 patients, 193 had exogenous tumors, and 83 had endogenous tumors. Tumor growth patterns were significantly related to age, rupture status, resection style, tumor site, tumor size, and intraoperative bleeding. According to Kaplan‒Meier curve analysis, the tumor growth pattern among patients with 2-5 cm diameter tumors was significantly correlated with worse progression-free survival (PFS). Ultimately, multivariate analyses identified the Ki-67 index (P = 0.008), surgical history (P = 0.031), and resection style (P = 0.045) as independent prognostic markers for PFS.
conclusionsAlthough gastric stromal tumors with a diameter of 2-5 cm are classified as low risk, the prognosis is lower for exogenous tumors than for endogenous tumors, and exogenous gastric stromal tumors have a risk of recurrence. Consequently, clinicians should be vigilant regarding the prognosis of patients with this type of tumor.
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