Evidence map›Paper›PMID 37120531›Full record

ArticleAnnals of clinical microbiology and antimicrobials2023

Emergence and clonal dissemination of KPC-3-producing Pseudomonas aeruginosa in China with an IncP-2 megaplasmid.

Haoyu Ge, Jie Qiao, Jiahao Zheng, Hao Xu, Ruishan Liu, Junhui Zhao, Ruyan Chen, Chenyu Li, Xiaobing Guo, Beiwen Zheng

Open access · goldAbstract read
In one paragraph

Article in Annals of clinical microbiology and antimicrobials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Role of Mobilome in Carbapenem Resistance.Antibiotics (Basel, Switzerland) · 2026
    Review
  3. Coexistence of blaScientific reports · 2025
    Article
  4. Article
  5. Emergence of plasmid-borneMicrobiology spectrum · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Haoyu Ge *Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Jie Qiao *Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Jiahao Zheng *Institute of Animal Quarantine, Chinese Academy of Inspection and Quarantine, Beijing, 100176, China.
Hao XuCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Ruishan LiuCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Junhui ZhaoSchool of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Ruyan ChenDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chenyu LiDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaobing GuoDepartment of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. gxbing928@zzu.edu.cn.
Beiwen ZhengCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, China. zhengbw@zju.edu.cn.
First Affiliated Hospital of Zhengzhou University · CNFirst Affiliated Hospital Zhejiang University · CNZhejiang University · CNChinese Academy of Inspection and Quarantine · CNZhejiang Chinese Medical University · CN

Funding

CAMS Innovation Fund for Medical Sciences 2019-I2M-5-045Henan Province Medical Science and Technology Research Project Joint Construction Project LHGJ20190232National Natural Science Foundation of China 82072314the Fundamental Research Funds for the Central Universities 2022ZFJH003the Research Project of Jinan Microecological Biomedicine Shandong Laboratory JNL-2022011B
6 · The paper itself

Abstract

backgroundDespite the global prevalence of Klebsiella pneumoniae Carbapenemase (KPC)-type class A β-lactamases, occurrences of KPC-3-producing isolates in China remain infrequent. This study aims to explore the emergence, antibiotic resistance profiles, and plasmid characteristics of bla

methodsSpecies identification was performed by MALDI-TOF-MS, and antimicrobial resistance genes (ARGs) were identified by polymerase chain reaction (PCR). The characteristics of the target strain were detected by whole-genome sequencing (WGS) and antimicrobial susceptibility testing (AST). Plasmids were analyzed by S1-nuclease pulsed-field gel electrophoresis(S1-PFGE), Southern blotting and transconjugation experiment.

resultsFive P. aeruginosa strains carrying bla

conclusionsThe emergence of a multidrug resistance IncP-2 megaplasmid and clonal transmission of bla

Indexed as

Klebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesChinaHumansMultilocus Sequence TypingPlasmidsPseudomonas aeruginosaAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesBla KPC-3CarbapenemaseClonal disseminationIncP-2 megaplasmidPseudomonas aeruginosaST1076

Identifiers

PMID37120531
PMCPMC10149002
OpenAlexW4367367842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.