Evidence map›Paper›PMID 37120514›Full record

ArticleBMC urology2023

Performing a sperm DNA fragmentation test in addition to semen examination based on the WHO criteria can be a more accurate diagnosis of IVF outcomes.

Tsuyoshi Okubo, Noriyuki Onda, Teruaki Hayashi, Tatsuya Kobayashi, Kenji Omi, Tomoya Segawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tsuyoshi OkuboShimbashi Yume Clinic, 2-5-1 Shimbashi Minato-ku, Tokyo, 105-0004, Japan. t-okubo@yumeclinic.net.ORCID http://orcid.org/0000-0002-6915-3633
Noriyuki OndaShimbashi Yume Clinic, 2-5-1 Shimbashi Minato-ku, Tokyo, 105-0004, Japan.
Teruaki HayashiShimbashi Yume Clinic, 2-5-1 Shimbashi Minato-ku, Tokyo, 105-0004, Japan.
Tatsuya KobayashiDepartment of Reproductive Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana Chuo-ku, Chiba, 260-0856, Japan.
Kenji OmiShimbashi Yume Clinic, 2-5-1 Shimbashi Minato-ku, Tokyo, 105-0004, Japan.
Tomoya SegawaShimbashi Yume Clinic, 2-5-1 Shimbashi Minato-ku, Tokyo, 105-0004, Japan.
Chiba University · JPMinebeaMitsumi (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe analyzed the sperm DNA fragmentation index (DFI) and general semen test based on the World Health Organization (WHO) criteria and compared the two tests using semen factors. In addition, we examined whether DFI is a reliable parameter associated with in vitro fertilization (IVF) outcomes.

methodsSperm chromatin dispersion (SCD) and general semen tests were conducted in accordance with the WHO 2010 guidelines, and correlations between the two tests were investigated. The WHO criteria were set as the cutoff values for each of the following factors: semen volume, concentration, total sperm count, motility, and normal morphology, and compared with the DFI results.

resultsThe subjects had a mean sperm DFI of 15.3% ± 12.6%, and the DFI increased with age. In contrast, motility and normal morphology decreased as the DFI increased. Patients who satisfied the WHO criteria in terms of concentration, total sperm count, and motility had a significantly lower DFI than those who did not satisfy the criteria. Therefore, evaluation with a general semen test based on the WHO criteria should be regarded as a qualitative evaluation of all factors other than semen volume and normal morphology.

conclusionsHigh DFI (≥ 30%) caused a low blastocyst development rate following intracytoplasmic sperm injection. Male infertility due to DFI should be suspected when IVF results are poor despite normal semen findings based on the WHO criteria. The results of this study suggest that the SCD test may more accurately evaluate the correlation between IVF clinical outcomes and male infertility. Therefore, it is important to focus on DFI measurements.

Indexed as

Infertility, MaleSemenDNA FragmentationFertilization in VitroHumansMaleSpermatozoaBlastocyst developmentHuman spermatozoaInfertility of maleSemen examinationSperm DNA fragmentationSperm morphology

Identifiers

PMID37120514
PMCPMC10148994
OpenAlexW4367394532

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.