ArticleNPJ digital medicine2023
Circadian rhythm biomarker from wearable device data is related to concurrent antidepressant treatment response.
Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Digital phenotyping and digital monitoring technologies for relapse detection in mental health: a systematic review.BMC psychiatry · 2026Pooled it
- The Role of Digital Biomarkers in Physiological Signal-Based Depression Assessment: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Obesity-related differences in amygdala and hippocampal volume and metabolism before and after a placebo-controlled antidepressant trial in major depressive disorder.Scientific reports · 2026Trial
- Investigating the relationship between hippocampus/dentate gyrus volume and hypothalamus metabolism in participants with major depressive disorder.Scientific reports · 2024Trial
- Circadian Regulation and Pain: A Systematic Review of the Association Between Rest-Activity Rhythm and Pain-Related Outcomes.Clocks & sleep · 2026Review
- Sensor-Equipped Digital Technologies for Monitoring and Detecting Depressive Disorders: A Systematic Review.Health science reports · 2026Review
- Exploring the feasibility of modeling next-day fatigue and sleepiness using digital sleep tracker data in neurodegenerative and immune-mediated inflammatory diseases.Frontiers in digital health · 2026Article
- Advanced biomaterials and digital twins for precision psychiatry: neuroimmune modulation and AI-guided therapeutics.Frontiers in bioengineering and biotechnology · 2026Article
- Circadian rhythms are disrupted in patients and preclinical models of Machado-Joseph disease.Brain : a journal of neurology · 2025Article
- More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors.Epilepsia · 2025Article
- Detection and Analysis of Circadian Biomarkers for Metabolic Syndrome Using Wearable Data: Cross-Sectional Study.JMIR medical informatics · 2025Article
- Development of a Cohesive Predictive Model for Substance Use Disorder Rehabilitation Using Passive Digital Biomarkers, Psychological Assessments, and Automated Facial Emotion Recognition: Protocol for a Prospective Cohort Study.JMIR research protocols · 2025Article
- Bibliometric and visual analysis of circadian rhythms in depression from 2004 to 2024.Annals of general psychiatry · 2025Article
- The implementation of digital biomarkers in the diagnosis, treatment and monitoring of mood disorders: a narrative review.Frontiers in digital health · 2025Review
- The real-world association between digital markers of circadian disruption and mental health risks.NPJ digital medicine · 2024Article
- Psychotherapy 2.0 - Application context and effectiveness of sensor technology in psychotherapy with children and adolescents: A systematic review.Internet interventions · 2024Review
- Longitudinal Assessment of Seasonal Impacts and Depression Associations on Circadian Rhythm Using Multimodal Wearable Sensing: Retrospective Analysis.Journal of medical Internet research · 2024Article
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Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Major depressive disorder (MDD) is associated with circadian rhythm disruption. Yet, no circadian rhythm biomarkers have been clinically validated for assessing antidepressant response. In this study, 40 participants with MDD provided actigraphy data using wearable devices for one week after initiating antidepressant treatment in a randomized, double-blind, placebo-controlled trial. Their depression severity was calculated pretreatment, after one week and eight weeks of treatment. This study assesses the relationship between parametric and nonparametric measures of circadian rhythm and change in depression. Results show significant association between a lower circadian quotient (reflecting less robust rhythmicity) and improvement in depression from baseline following first week of treatment (estimate = 0.11, F = 7.01, P = 0.01). There is insufficient evidence of an association between circadian rhythm measures acquired during the first week of treatment and outcomes after eight weeks of treatment. Despite this lack of association with future treatment outcome, this scalable, cost-effective biomarker may be useful for timely mental health care through remote monitoring of real-time changes in current depression.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.