Evidence map›Paper›PMID 37119810›Full record

ArticleGenetics2023

Rare disease research resources at the Rat Genome Database.

Mary L Kaldunski, Jennifer R Smith, Kent C Brodie, Jeffrey L De Pons, Wendy M Demos, Adam C Gibson, G Thomas Hayman, Logan Lamers, Stanley J F Laulederkind, Ketaki Thorat and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mary L KaldunskiThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jennifer R SmithThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Kent C BrodieClinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jeffrey L De PonsThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Wendy M DemosThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Adam C GibsonThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
G Thomas HaymanThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Logan LamersThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Stanley J F LaulederkindThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Ketaki ThoratThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Jyothi ThotaThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Marek A TutajThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Monika TutajThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Mahima VediThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Shur-Jen WangThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Stacy ZacherFinance and Administration, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Melinda R DwinellThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Anne E KwitekThe Rat Genome Database, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0003-1024-4116

Funding

RAT GENOME DATABASER01HL064541 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ANNE E. KWITEK · 1999 to 2026
$50.0M
Text mining in the CloudU24HG010859 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CAROL J BULT, PAUL Warren STERNBERG · 2019 to 2026
$42.0M
Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2M
Sequencing Coordination and Data Analysis CoreP01HL149620 · NHLBI · UNIVERSITY OF ARIZONA · PI LIANG, MINGYU · 2020 to 2024
$11.8M
NHGRI NIH HHS U24 HG010859NHLBI NIH HHS P01 HL084207NHLBI NIH HHS P01 HL149620NHLBI NIH HHS R01 HL064541
6 · The paper itself

Abstract

Rare diseases individually affect relatively few people, but as a group they impact considerable numbers of people. The Rat Genome Database (https://rgd.mcw.edu) is a knowledgebase that offers resources for rare disease research. This includes disease definitions, genes, quantitative trail loci (QTLs), genetic variants, annotations to published literature, links to external resources, and more. One important resource is identifying relevant cell lines and rat strains that serve as models for disease research. Diseases, genes, and strains have report pages with consolidated data, and links to analysis tools. Utilizing these globally accessible resources for rare disease research, potentiating discovery of mechanisms and new treatments, can point researchers toward solutions to alleviate the suffering of those afflicted with these diseases.

Indexed as

GenomeRare DiseasesAnimalsDatabases, GeneticRatsontologiesrare diseasesRat Genome Database

Identifiers

PMID37119810
PMCPMC10411567

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.