Evidence map›Paper›PMID 37119780›Full record

ArticleGeneral hospital psychiatry

Written exposure therapy for treatment of perinatal PTSD among women with comorbid PTSD and SUD: A pilot study examining feasibility, acceptability, and preliminary effectiveness.

Yael I Nillni, Tithi D Baul, Emilie Paul, Laura B Godfrey, Denise M Sloan, Sarah E Valentine

Registry-linked trialAbstract read
In one paragraph

Article in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06771817 (Feasibility and Preliminary Effectiveness of Written Exposure Therapy), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06771817 naactive not recruitingnot on this map

Feasibility and Preliminary Effectiveness of Written Exposure Therapy (WET) for Pregnant or Postpartum Adolescents and Youth With Post-Traumatic Stress Disorder (PTSD) in an Open Pilot Trial

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2025 to 2026Enrolled30ConditionsPost-Traumatic Stress Disorder in Adolescence, PTSD - Post Traumatic Stress Disorder, PTSD and Trauma-related Symptoms, Pregnancy and PTSDArmsWritten Exposure Therapy
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. A systematic review of written exposure therapy for the treatment of posttraumatic stress symptoms.Psychological trauma : theory, research, practice and policy · 2024
    Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Clinical Education: Addressing Prior Trauma and Its Impacts in Medical Settings.Journal of clinical psychology in medical settings · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yael I NillniNational Center for PTSD, Women's Health Sciences Division at VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. Electronic address: ynillni@bu.edu.
Tithi D BaulDepartment of Psychiatry, Boston Medical Center, Boston, MA, USA. Electronic address: tithi.baul@bmc.org.
Emilie PaulDepartment of Psychiatry, Boston Medical Center, Boston, MA, USA; College of Liberal Arts and Sciences, St. John's University, Queens, NY, USA. Electronic address: emilie.paul21@stjohns.edu.
Laura B GodfreyDepartment of Psychiatry, Boston Medical Center, Boston, MA, USA. Electronic address: laura.godfrey@bmc.org.
Denise M SloanDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; National Center for PTSD, Behavioral Science Division at VA Boston Healthcare System, Boston, MA, USA. Electronic address: denise.sloan@va.gov.
Sarah E ValentineDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA; Department of Psychiatry, Boston Medical Center, Boston, MA, USA. Electronic address: sarah.valentine@bmc.org.

Funding

A Non-Inferiority Trial Testing Delivery of Written Exposure Therapy by Community Health Workers for Treatment of PTSD During PregnancyR01HD107282 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Yael I Nillni · 2022 to 2026
$2.5M
An implementation science approach to optimizing evidence-based treatments for posttraumatic stress disorder (PTSD) for non-specialty settingsK23MH117221 · NIMH · BOSTON MEDICAL CENTER · PI VALENTINE, SARAH E · 2018 to 2022
$908k
PTSD-Related Neurobiological Mediators of Negative Pregnancy OutcomesK23HD087428 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI NILLNI, YAEL I · 2017 to 2020
$616k
NICHD NIH HHS K23 HD087428NICHD NIH HHS R01 HD107282NIMH NIH HHS K23 MH117221
6 · The paper itself

Abstract

objectiveThis pilot open trial examined the feasibility, acceptability, and preliminary effectiveness of Written Exposure Therapy (WET), a 5-session evidence-based intervention for posttraumatic stress disorder (PTSD) during pregnancy. Participants were pregnant women with comorbid PTSD and substance use disorder (SUD) receiving prenatal care in a high risk obstetrics-addictions clinic.

methodsA total of 18 participants with probable PTSD engaged in the intervention, and 10 completed the intervention and were included in outcome analyses. Wilcoxon's Signed-Rank analyses were used to evaluate PTSD and depression symptoms and craving at pre-intervention to post-intervention and pre-intervention to the 6-month postpartum follow-up. Engagement and retention in WET and therapist fidelity to the intervention manual were used to assess feasibility. Quantitative and qualitative measures of patient satisfaction were used to assess acceptability.

resultsPTSD symptoms significantly decreased from pre-intervention to post-intervention (S = 26.6, p = 0.006), which sustained at the 6-month postpartum follow-up (S = 10.5, p = 0.031). Participant satisfaction at post-intervention was high. Therapists demonstrated high adherence to the intervention and excellent competence.

conclusionsWET was a feasible and acceptable treatment for PTSD in this sample. Randomized clinical trial studies with a general group of pregnant women are needed to expand upon these findings and perform a full-scale test of effectiveness of this intervention.

Indexed as

Implosive TherapyPregnancy ComplicationsStress Disorders, Post-TraumaticSubstance-Related DisordersAdultCravingDepressionFeasibility StudiesFemaleHumansPilot ProjectsPregnancyDepressionPosttraumatic stress disorderPregnancySubstance use disorderWritten exposure therapy

Identifiers

PMID37119780
PMCPMC10587907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.