ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Nerve-on-a-Chip Derived Biomimicking Microfibers for Peripheral Nerve Regeneration.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- From flow to form: structuring and patterning hydrogels using microfluidic approaches.Lab on a chip · 2026Review
- A Three-Dimensional Biomimetic In Vitro Model to Simulate Schwann Cell-Mediated Peripheral Nerve Repair.Gels (Basel, Switzerland) · 2026Article
- [Extracellular matrix materials and tissue regeneration and repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Nerve tissue model on a micropatterned surface: Axon guidance and neural regeneration.Journal of materials science. Materials in medicine · 2025Article
- A Bio-Inspired Artificial Nerve Simulator for Ex Vivo Validation of Implantable Neural Interfaces Equipped with Plug Electrodes.Bioengineering (Basel, Switzerland) · 2025Article
- Conductive Nerve Guidance Conduits Loaded With Adipose Mesenchymal Stem Cells for Peripheral Nerve Regeneration.Smart medicine · 2025Article
- Engineering neural recovery: Micro/nano-structured materials for nerve regeneration.Materials today. Bio · 2025Review
- Bioinspired micro-structured fibers for biomedical applications.Bioactive materials · 2025Review
- Multifunctional hydrogel loaded with 4-octyl itaconate and exosomes to induce bone regeneration for diabetic infected bone defect via Keap1-Nrf2 pathway.Materials today. Bio · 2025Article
- Organs-on-a-Chip Recapitulating the Gut-Islets Axis for Endocrine Hormone Secretion Regulator Evaluation.Research (Washington, D.C.) · 2025Article
- Micro- and nano-fibers for organ-on-a-chip: Construction, applications, and prospects.Materials today. Bio · 2024Review
- Emerging approaches for the development of artificial islets.Smart medicine · 2024Review
- Decellularized Tumor Tissues Integrated with Polydopamine for Wound Healing.Research (Washington, D.C.) · 2024Article
- Nerve-on-a-Chip Derived Biomimicking Microfibers for Peripheral Nerve Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Microfluidic organ-on-a-chip for modeling coronary artery disease: Recent applications, limitations and potential.Journal of tissue engineeringReview
- Dynamic three-dimensional coculture model: The future of tissue engineering applied to the peripheral nervous system.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Fibrous scaffolds have shown their advantages in tissue engineering, such as peripheral nerve regeneration, while most of the existing fiber-shaped scaffolds are with simple structures, and the in vitro performance for nerve regeneration lacks systematic analysis. Here, novel nerve-on-a-chip derived biomimicking microfibers for peripheral nerve regeneration are presented. The microfibers with controllable core-shell structures and functionalities are generated through capillary microfluidic devices. By integrating these microfibers into a multitrack-architectured chip, and coculturing them with nerve cells as well as gradient bioactive elements, the nerve-on-a-chip with the capabilities of systematically assessing the performances of nerve fiber formation in the hollow microfibers at in vitro level is constructed. Based on a rat sciatic nerve injury model, the rapid promotion ability is demonstrated of optimized microfibers in nerve regeneration and function recovery in vivo, which implies the credibility of the nerve-on-a-chip on biomimicking microfibers evaluation for peripheral nerve regeneration. Thus, it is convinced that the organ-on-a-chip will undoubtedly open up a new chapter in evaluating biological scaffolds for in vivo tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.