Evidence map›Paper›PMID 37119386›Full record

ArticleImmunogenetics2023

Germline-enforced enrichment for charged amino acids in TCR beta chain (TCRβ) complementarity determining region 3 (CDR-B3) alters T cell development, repertoire content, and antigen recognition.

Michael Levinson, Mohamed Khass, Peter D Burrows, Harry W Schroeder

Abstract read
PubMed Publisher
In one paragraph

Article in Immunogenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Michael LevinsonDivision of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Mohamed KhassDivision of Investigative Medicine, Center of Immunobiology, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA. mohamed.khass@med.wmich.edu.
Peter D BurrowsDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Harry W SchroederDivisions of Clinical Immunology and Rheumatology, Departments of Medicine, Microbiology and Genetics, University of Alabama at Birmingham, Birmingham, AL, USA. hschroeder@uabmc.edu.
University of Alabama at Birmingham · USWestern Michigan University · US

Funding

CSR NIH HHS AI090902 (HWS)CSR NIH HHS AI163555
6 · The paper itself

Abstract

T cell receptor beta chain (TCRβ) diversity (Dβ) gene segments are highly conserved across evolution, with trout Dβ1 sequence identical to human and mouse Dβ1. A key conserved feature is enrichment for glycine in all three Dβ reading frames (RFs). Previously, we found that replacement of mouse Dβ1 with a typical immunoglobulin D

Indexed as

Amino AcidsComplementarity Determining RegionsAmino Acid SequenceAnimalsGerm CellsGlycineHumansImmunodominant EpitopesMiceReceptors, Antigen, T-Cell, alpha-betaTyrosineAmino AcidsComplementarity Determining RegionsGlycineImmunodominant EpitopesReceptors, Antigen, T-Cell, alpha-betaTyrosineAntigen recognitionCDR-B3Charged amino acidsGermlineRepertoireT cell development

Identifiers

PMID37119386
OpenAlexW4367369366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.