Trial reportJournal of clinical monitoring and computing2023
Hypotension Prediction Index guided Goal Directed therapy and the amount of Hypotension during Major Gynaecologic Oncologic Surgery: a Randomized Controlled clinical Trial.
Trial report in Journal of clinical monitoring and computing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hemodynamic Monitoring and Prediction of Hypotension Through the HPI Algorithm During Major Gynecologic Oncologic Surgery: a Randomized Controlled Trial
HEMOdynamic Proactive Management During Cytoreductive Surgery and Intraperitoneal hyPErthermic Chemotherapy for Advanced Ovarian Cancer
Who cites it
27 citing papers in PubMed, 7 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Does Hypotension Prediction Index limit the occurrence of postoperative complications associated with intraoperative hypotension? A systematic review and model-averaged Bayesian meta-analysis of statistically sound studies.Journal of anesthesia · 2026Pooled it
- Hypotension prediction index in the prediction of better outcomes: a systematic review and meta-analysis.Korean journal of anesthesiology · 2026Pooled it
- Clinical performance of machine-learning algorithms to predict intraoperative hypotension: a meta-analysis.BMC surgery · 2025Pooled it
- Intraoperative hypotension prediction in cardiac and noncardiac procedures: is HPI truly worthwhile? A systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Beyond the debut: unpacking six years of Hypotension Prediction Index software in intraoperative hypotension prevention - a systematic review and meta-analysis.Journal of clinical monitoring and computing · 2024Pooled it
- Artificial intelligence-assisted interventions for perioperative anesthetic management: a systematic review and meta-analysis.BMC anesthesiology · 2024Pooled it
- Predictive ability of hypotension prediction index and machine learning methods in intraoperative hypotension: a systematic review and meta-analysis.Journal of translational medicine · 2024Pooled it
- The Effect of Using Hypotension Prediction Index to Reduce Intraoperative Hypotension in Elective Cesarean Sections: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2026Trial
- Effectiveness of hypotension prediction index software in reducing intraoperative hypotension in prolonged prone-position spine surgery: a single-center clinical trial.Journal of clinical monitoring and computing · 2025Trial
- Intraoperative hypotension during robotic-assisted radical prostatectomy: A randomised controlled trial comparing standard goal-directed fluid therapy with hypotension prediction index-guided goal-directed fluid therapy.European journal of anaesthesiology · 2025Trial
- Arterial dP/dtJournal of clinical medicine · 2026Article
- Performance of the Hypotension Prediction Index as an indicator of hypotensive haemodynamic instability in surgical patients.Perioperative medicine (London, England) · 2026Article
- Association of intraoperative hypotension and acute kidney injury in noncardiac surgery patients: a post hoc secondary analysis of the EU HYPROTECT registry.Journal of clinical monitoring and computing · 2026Article
- Comparison of the Hypotension Prediction Index and pulse pressure variation-guided haemodynamic management for intra-operative hypotension during kidney transplant: A randomised controlled trial.Indian journal of anaesthesia · 2026Article
- Hypotension Prediction Index Software Compared with Standard Advanced Haemodynamic Monitoring in Patients Undergoing Major Aortic Surgery: A Retrospective Study.Journal of clinical medicine · 2025Article
- Ability of the hypotension prediction index to predict hypotension in patients with septic shock in the intensive care unit.Scientific reports · 2025Article
- Goal-directed therapy: what is the goal again?Perioperative medicine (London, England) · 2025Review
- Impact of FloTrac versus hypotension prediction index (HPI)-guided haemodynamic management on intraoperative hypotension in kidney transplantation: A retrospective observational study.Indian journal of anaesthesia · 2025Article
- AI for the hemodynamic assessment of critically ill and surgical patients: focus on clinical applications.Annals of intensive care · 2025Review
- The hypotension prediction index in major abdominal surgery - A prospective randomised clinical trial protocol.Contemporary clinical trials communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intraoperative hypotension (IOH) is associated with increased morbidity and mortality. Hypotension Prediction Index (HPI) is a machine learning derived algorithm that predicts IOH shortly before it occurs. We tested the hypothesis that the application of the HPI in combination with a pre-defined Goal Directed Therapy (GDT) hemodynamic protocol reduces IOH during major gynaecologic oncologic surgery. We enrolled women scheduled for major gynaecologic oncologic surgery under general anesthesia with invasive arterial pressure monitoring. Patients were randomized to a GDT protocol aimed at optimizing stroke volume index (SVI) or hemodynamic management based on HPI guidance in addition to GDT. The primary outcome was the amount of IOH, defined as the timeweighted average (TWA) mean arterial pressure (MAP) < 65 mmHg. Secondary outcome was the TWA-MAP < 65 mmHg during the first 20 min after induction of GA. After exclusion of 10 patients the final analysis included 60 patients (30 in each group). The median (25-75th IQR) TWA-MAP < 65 mmHg was 0.14 (0.04-0.66) mmHg in HPI group versus 0.77 (0.36-1.30) mmHg in Control group, P < 0.001. During the first 20 min after induction of GA, the median TWA-MAP < 65 mmHg was 0.53 (0.06-1.8) mmHg in the HPI group and 2.15 (0.65-4.2) mmHg in the Control group, P = 0.001. Compared to a GDT protocol aimed to SVI optimization, a machine learning-derived algorithm for prediction of IOH combined with a GDT hemodynamic protocol, reduced IOH and hypotension after induction of general anesthesia in patients undergoing major gynaecologic oncologic surgery.Trial registration number: NCT04547491. Date of registration: 10/09/2020.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.