Evidence map›Paper›PMID 37119306›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2023

The impact of perinatal brain injury on retinal nerve fiber layer thickness and optic nerve head parameters of premature children.

Yaroslava Wenner, Kira Kunze, Apostolos Lazaridis, Vanessa Brauer, Volker Besgen, Petra Davidova, Walter Sekundo, Rolf F Maier

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yaroslava WennerDepartment of Ophthalmology, Philipps-University, Universitätsklinikum Giessen and Marburg GmbH, Marburg Campus, Marburg, Germany. Yaroslava.Wenner@kgu.de.ORCID http://orcid.org/0000-0002-1914-8174
Kira KunzeDepartment of Ophthalmology, Philipps-University, Universitätsklinikum Giessen and Marburg GmbH, Marburg Campus, Marburg, Germany.
Apostolos LazaridisDepartment of Ophthalmology, Philipps-University, Universitätsklinikum Giessen and Marburg GmbH, Marburg Campus, Marburg, Germany.
Vanessa BrauerDepartment of Ophthalmology, Philipps-University, Universitätsklinikum Giessen and Marburg GmbH, Marburg Campus, Marburg, Germany.
Volker BesgenDepartment of Ophthalmology, Philipps-University, Universitätsklinikum Giessen and Marburg GmbH, Marburg Campus, Marburg, Germany.
Petra DavidovaDepartment of Ophthalmology, Goethe-University, Theodor-Stern-Kai 7, 60590, Frankfurt Am Main, Germany.
Walter SekundoDepartment of Ophthalmology, Philipps-University, Universitätsklinikum Giessen and Marburg GmbH, Marburg Campus, Marburg, Germany.
Rolf F MaierDepartment of Paediatrics, Philipps-University, Universitätsklinikum Giessen and Marburg GmbH, Marburg Campus, Marburg, Germany.
Universitätsklinikum Gießen und Marburg · DEGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to evaluate the impact of birth weight (BW), gestational age (GA), retinopathy of prematurity (ROP), and perinatal brain injury (PBI) on optic nerve head (ONH) parameters and nerve fiber layer thickness (RNFLT) in preterm children.

methodsONH parameters and RNFLT were examined prospectively in 5-15-year-old preterm and full-term children with RTVue-100 OCT (Optovue, USA). The parameters of the two groups were compared and possible influences of BW, GA, ROP, and PBI analyzed in preterm children.

resultsIn total, 51 full-term and 55 preterm children were included. The mean age was 9.98 ± 3.4 years in full-term and 10.0 ± 2.5 years in preterm children. The mean GA in preterm children was 29.6 ± 3.8 weeks with a BW of 1523 ± 732 g. RNFLT was significantly lower in preterm than in full-term children in all but temporal quadrants. Cup area, volume, cup/disc area ratio, and horizontal cup/disc ratio (CDR) were significantly larger and rim area significantly thinner in preterm children. GA was positively correlated with superior, nasal, and overall RNFLT and negatively correlated with cup area, volume, and horizontal CDR. ROP stage correlated negatively with superior and nasal RNFLT. PBI was the only significant predicting factor for RNFL thinning in all but temporal quadrant in multiple regression analysis. Preterm children with PBI had a significantly larger optic cup (CDR 0.70 ± 0.33 vs. 0.37 ± 0.27) and thinner optic rim.

conclusionPBI correlated strongest with RNFL thinning, a thinner optic rim, and a larger optic cup in preterm children and should be evaluated in each patient to prevent incorrect diagnosis like glaucoma.

Indexed as

Brain InjuriesOptic DiskPremature BirthRetinopathy of PrematurityAdolescentBirth WeightChildChild, PreschoolFemaleHumansInfant, NewbornNerve FibersRetinal Ganglion CellsTomography, Optical CoherenceOCTOptic nervePerinatal brain injuryPreterm childrenRNFL

Identifiers

PMID37119306
PMCPMC10432335
OpenAlexW4367394133

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.