Evidence map›Paper›PMID 37119279›Full record

ReviewClinical and experimental immunology2023

Protective and pathogenic functions of innate lymphoid cells in transplantation.

Martin L Mak, Kyle T Reid, Sarah Q Crome

Open access · bronzeAbstract readReview
In one paragraph

Review in Clinical and experimental immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Cellular and Molecular Aspects of Chronic Rejection.Results and problems in cell differentiation · 2026
    Review
  3. Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Martin L MakDepartment of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0001-6709-7802
Kyle T ReidDepartment of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0003-4339-9317
Sarah Q CromeDepartment of Immunology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.ORCID 0000-0001-5117-7453
University Health Network · CA

Funding

Canada First Research Excellence FundCanada Foundation for Innovation 38308Canadian Institutes for Health Research 169084
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a family of lymphocytes with essential roles in tissue homeostasis and immunity. Along with other tissue-resident immune populations, distinct subsets of ILCs have important roles in either promoting or inhibiting immune tolerance in a variety of contexts, including cancer and autoimmunity. In solid organ and hematopoietic stem cell transplantation, both donor and recipient-derived ILCs could contribute to immune tolerance or rejection, yet understanding of protective or pathogenic functions are only beginning to emerge. In addition to roles in directing or regulating immune responses, ILCs interface with parenchymal cells to support tissue homeostasis and even regeneration. Whether specific ILCs are tissue-protective or enhance ischemia reperfusion injury or fibrosis is of particular interest to the field of transplantation, beyond any roles in limiting or promoting allograft rejection or graft-versus host disease. Within this review, we discuss the current understanding of ILCs functions in promoting immune tolerance and tissue repair at homeostasis and in the context of transplantation and highlight where targeting or harnessing ILCs could have applications in novel transplant therapies.

Indexed as

Graft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunity, InnateLymphocytesTransplantation, Homologousgraft-versus-host diseasehematopoietic stem cell transplantimmune regulationimmune toleranceinnate lymphoid cellsischemia reperfusion injurynatural killer cellsrejectiontransplantation

Identifiers

PMID37119279
PMCPMC10324558
OpenAlexW4367394578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.