Evidence map›Paper›PMID 37119138›Full record

ArticleCell reports2023

Identification of an adipose tissue-resident pro-preadipocyte population.

Min Chen, Soochi Kim, Liang Li, Sourav Chattopadhyay, Thomas A Rando, Brian J Feldman

Abstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Min ChenDepartment of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, CA 94158, USA.
Soochi KimDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.
Liang LiDepartment of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, CA 94158, USA.
Sourav ChattopadhyayDepartment of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, CA 94158, USA.
Thomas A RandoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Broad Stem Cell Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA.
Brian J FeldmanDepartment of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, CA 94158, USA; Nutrition and Obesity Research Center, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: brian.feldman@ucsf.edu.

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Aging and Stem Cell ResilienceR01AG068667 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RANDO, THOMAS A. · 2021 to 2025
$2.8M
Complement Components as Mediators of Cell and Tissue AgingR01AG055755 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI RANDO, THOMAS A. · 2017 to 2021
$2.2M
Integrated Systemic and Adipose Depot-Specific Regulation of AdipogenesisR01DK114217 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FELDMAN, BRIAN J · 2017 to 2021
$2.1M
Molecular responses and physiological implications to systemic stimuli in adipocyte progenitor cellsR01DK132404 · NIDDK · YALE UNIVERSITY · PI FELDMAN, BRIAN J · 2022 to 2024
$1.6M
NIA NIH HHS R01 AG055755NIA NIH HHS R01 AG068667NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK114217NIDDK NIH HHS R01 DK132404
6 · The paper itself

Abstract

Elucidating the transitional stages that define the pathway stem cells progress through during differentiation advances our understanding of biology and fosters the identification of therapeutic opportunities. However, distinguishing progenitor cells from other cell types and placing them in an epistatic pathway is challenging. This is exemplified in the adipocyte lineage, where the stromal vascular fraction (SVF) from adipose tissue is enriched for progenitor cells but also contains heterogeneous populations of cells. Single-cell RNA sequencing (scRNA-seq) has begun to facilitate the deconvolution of cell types in the SVF, and a hierarchical structure is emerging. Here, we use scRNA-seq to discover a population of CD31

Indexed as

Adipose TissueStromal CellsAdipocytesCell DifferentiationStem Cellsadipocyte progenitor celladipognesisadiposeCD44CP: MetabolismCP: Stem cell researchNocturnin

Identifiers

PMID37119138
PMCPMC10370484

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.