ArticleCell reports2023
High-fidelity encoding of mechanostimuli by tactile food-sensing neurons requires an ensemble of ion channels.
Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Identification of bacterial signals that modulate enteric sensory neurons to influence behavior in C. elegans.Current biology : CB · 2026Article
- Mechanical cues as immunomodulators in neuroinflammation-driven spinal sensitization: analgesic mechanisms and therapeutic strategies.Frontiers in immunology · 2026Review
- Rewarding touch limits lifespan through neural to intestinal signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Strongyloides species exhibit distinct behaviors on the skin of different mammals.BMC infectious diseases · 2025Article
- Identification of bacterial signals that modulate enteric sensory neurons to influence behavior inbioRxiv : the preprint server for biology · 2025Article
- Dopamine signaling drives skin invasion by human-infective nematodes.Nature communications · 2025Article
- Food sensing controlsScience advances · 2025Article
- Chemosensory detection of polyamine metabolites guidesScience advances · 2024Article
- Neural mechanisms of dopamine function in learning and memory inNeuronal signaling · 2024Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The nematode C. elegans uses mechanosensitive neurons to detect bacteria, which are food for worms. These neurons release dopamine to suppress foraging and promote dwelling. Through a screen of genes highly expressed in dopaminergic food-sensing neurons, we identify a K2P-family potassium channel-TWK-2-that damps their activity. Strikingly, loss of TWK-2 restores mechanosensation to neurons lacking the NOMPC-like channel transient receptor potential 4 (TRP-4), which was thought to be the primary mechanoreceptor for tactile food sensing. The alternate mechanoreceptor mechanism uncovered by TWK-2 mutation requires three Deg/ENaC channel subunits: ASIC-1, DEL-3, and UNC-8. Analysis of cell-physiological responses to mechanostimuli indicates that TRP and Deg/ENaC channels work together to set the range of analog encoding of stimulus intensity and to improve signal-to-noise characteristics and temporal fidelity of food-sensing neurons. We conclude that a specialized mechanosensory modality-tactile food sensing-emerges from coordination of distinct force-sensing mechanisms housed in one type of sensory neuron.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.