ArticleAging cell2023
Buildup from birth onward of short telomeres in human hematopoietic cells.
Article in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 15 citations in OpenAlex.
- A Balanced Chromosomal Rearrangement Disrupting the Telomerase RNA Component Gene Causes Short Telomere-Mediated Pulmonary Fibrosis.International journal of molecular sciences · 2026Article
- Diagnosis and management of adult telomere biology disorders.Haematologica · 2026Review
- No Evidence That Life History Strategies Shape Within-Body Mosaics of Ageing.Molecular ecology · 2025Article
- Telomere function and regulation from mouse models to human ageing and disease.Nature reviews. Molecular cell biology · 2025Review
- Telomeres in Space.Aging cell · 2025Article
- Long donor leukocyte telomeres raise risk of severe COVID-19 in recipients of allogeneic hematopoietic cell transplant.Frontiers in immunology · 2025Article
- Methods for telomere length measurement: an update on current technologies and emerging approaches.Frontiers in molecular biosciences · 2025Review
- High-throughput single telomere analysis using DNA microarray and fluorescent in situ hybridization.Nucleic acids research · 2024Article
- Insights into the length and breadth of methodologies harnessed to study human telomeres.Biomarker research · 2024Article
- Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease.Nature communications · 2024Article
- T-cell count and T-cell telomere length in patients with severe COVID-19.Frontiers in immunology · 2024Article
- Digital telomere measurement by long-read sequencing distinguishes healthy aging from disease.bioRxiv : the preprint server for biology · 2023Article
- Article
- The distribution and accumulation of the shortest telomeres in telomere biology disorders.British journal of haematology · 2023Article
- Article
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Telomere length (TL) limits somatic cell replication. However, the shortest among the telomeres in each nucleus, not mean TL, is thought to induce replicative senescence. Researchers have relied on Southern blotting (SB), and techniques calibrated by SB, for precise measurements of TL in epidemiological studies. However, SB provides little information on the shortest telomeres among the 92 telomeres in the nucleus of human somatic cells. Therefore, little is known about the accumulation of short telomeres with age, or whether it limits the human lifespan. To fill this knowledge void, we used the Telomere-Shortest-Length-Assay (TeSLA), a method that tallies and measures single telomeres of all chromosomes. We charted the age-dependent buildup of short telomeres (<3 kb) in human hematopoietic cells from 334 individuals (birth-89 years) from the general population, and 18 patients with dyskeratosis congenita-telomere biology disorders (DC/TBDs), whose hematopoietic cells have presumably reached or are close to their replicative limit. For comparison, we also measured TL with SB. We found that in hematopoietic cells, the buildup of short telomeres occurs in parallel with the shortening with age of mean TL. However, the proportion of short telomeres was lower in octogenarians from the general population than in patients with DC/TBDs. At any age, mean TL was longer and the proportion of short telomeres lower in females than in males. We conclude that though converging to the TL-mediated replicative limit, hematopoietic cell telomeres are unlikely to reach this limit during the lifespan of most contemporary humans.
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