Evidence map›Paper›PMID 37118885›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.

Mathew M Simpson, Ching Ching Lam, Jonathan M Goodman, Shankar Balasubramanian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Regulation of RNA methylation linked to drug resistance in gastric cancer.Frontiers in cell and developmental biology · 2025
    Review
  2. Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.Angewandte Chemie (International ed. in English) · 2023
    Article
  3. Selective Functionalisation of 5-Methylcytosine by Organic Photoredox Catalysis.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mathew M SimpsonYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.ORCID 0000-0003-1469-4827
Ching Ching LamYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.ORCID 0000-0001-7332-5656
Jonathan M GoodmanYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.ORCID 0000-0002-8693-9136
Shankar BalasubramanianYusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW, Cambridge, UK.ORCID 0000-0002-0281-5815

Funding

Cancer Research UK C9545/A19863Cancer Research UK C9681/A29214Wellcome TrustWellcome Trust 209441/Z/17/Z
6 · The paper itself

Abstract

The epigenetic modification 5-methylcytosine plays a vital role in development, cell specific gene expression and disease states. The selective chemical modification of the 5-methylcytosine methyl group is challenging. Currently, no such chemistry exists. Direct functionalisation of 5-methylcytosine would improve the detection and study of this epigenetic feature. We report a xanthone-photosensitised process that introduces a 4-pyridine modification at a C(sp

Indexed as

5-MethylcytosineElectronsCatalysisEpigenesis, GeneticOxidation-Reduction5-MethylcytosineC−H FunctionalizationNucleic AcidsPhotocatalysisRadicalsReaction Mechanisms

Identifiers

PMID37118885
PMCPMC10952617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.