Evidence map›Paper›PMID 37118841›Full record

ArticleBioelectronic medicine2023

Vagus nerve stimulation in the non-human primate: implantation methodology, characterization of nerve anatomy, target engagement and experimental applications.

Aaron J Suminski, Abigail Z Rajala, Rasmus M Birn, Ellie M Mueller, Margaret E Malone, Jared P Ness, Caitlyn Filla, Kevin Brunner, Alan B McMillan, Samuel O Poore and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioelectronic medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Aaron J SuminskiDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Abigail Z RajalaDepartment of Neuroscience, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI, 53705, USA.
Rasmus M BirnDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Ellie M MuellerDepartment of Neuroscience, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI, 53705, USA.
Margaret E MaloneDepartment of Neuroscience, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI, 53705, USA.
Jared P NessWisconsin Institute for Translational Neuroengineering, University of Wisconsin-Madison, Madison, WI, USA.
Caitlyn FillaDepartment of Neuroscience, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI, 53705, USA.
Kevin BrunnerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Alan B McMillanDepartment of Radiology, University of Wisconsin-Madison, Madison, WI, USA.
Samuel O PooreDivision of Plastic Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Justin C WilliamsDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Dhanabalan MuraliDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.
Andrea BrzeczkowskiDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Samuel A HurleyDepartment of Radiology, University of Wisconsin-Madison, Madison, WI, USA.
Aaron M DingleDivision of Plastic Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Weifeng ZengDivision of Plastic Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Wendell B LakeDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Kip A LudwigDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Luis C PopulinDepartment of Neuroscience, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI, 53705, USA. lpopulin@wisc.edu.ORCID http://orcid.org/0000-0003-3729-7728
University of Wisconsin–Madison · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
NIH HHS P51 OD011106
6 · The paper itself

Abstract

backgroundVagus nerve stimulation (VNS) is a FDA approved therapy regularly used to treat a variety of neurological disorders that impact the central nervous system (CNS) including epilepsy and stroke. Putatively, the therapeutic efficacy of VNS results from its action on neuromodulatory centers via projections of the vagus nerve to the solitary tract nucleus. Currently, there is not an established large animal model that facilitates detailed mechanistic studies exploring how VNS impacts the function of the CNS, especially during complex behaviors requiring motor action and decision making.

methodsWe describe the anatomical organization, surgical methodology to implant VNS electrodes on the left gagus nerve and characterization of target engagement/neural interface properties in a non-human primate (NHP) model of VNS that permits chronic stimulation over long periods of time. Furthermore, we describe the results of pilot experiments in a small number of NHPs to demonstrate how this preparation might be used in an animal model capable of performing complex motor and decision making tasks.

resultsVNS electrode impedance remained constant over months suggesting a stable interface. VNS elicited robust activation of the vagus nerve which resulted in decreases of respiration rate and/or partial pressure of carbon dioxide in expired air, but not changes in heart rate in both awake and anesthetized NHPs.

conclusionsWe anticipate that this preparation will be very useful to study the mechanisms underlying the effects of VNS for the treatment of conditions such as epilepsy and depression, for which VNS is extensively used, as well as for the study of the neurobiological basis underlying higher order functions such as learning and memory.

Indexed as

fMRIHistologyPETVagus nerve stimulation

Identifiers

PMID37118841
PMCPMC10148417
OpenAlexW4367310646

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.