Evidence map›Paper›PMID 37118766›Full record

ArticleParasites & vectors2023

Investigating potential sand fly vectors after the first reported outbreak of cutaneous leishmaniasis in Ghana.

Dziedzom K de Souza, Seth Offei Addo, Kwame Desewu, Chukwunonso O Nzelu, Mba T Mosore, Shirley Nimo-Paintsil, Naiki Attram, Maxwell Appawu, Michael D Wilson, Daniel A Boakye

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Dziedzom K de SouzaNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana. ddesouza@noguchi.ug.edu.gh.
Seth Offei Addo *Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana.
Kwame Desewu *Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana.
Chukwunonso O Nzelu *Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana.
Mba T MosoreNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana.
Shirley Nimo-PaintsilNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana.
Naiki AttramNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana.
Maxwell AppawuNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana.
Michael D WilsonNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana.
Daniel A BoakyeNoguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, LG 581, Legon, Accra, Ghana.
University of Ghana · GHNoguchi Memorial Institute for Medical Research · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeishmaniasis is a parasitic disease caused by species of the genus Leishmania, which are transmitted through the bite of infected female sand flies. Since the first reported outbreak of cutaneous leishmaniasis in Ghana, in 1999, there has been limited published information on its vectors and reservoir hosts there. Previous studies have shown strong dominance of the sand fly genus Sergentomyia over the genus Phlebotomus in Ghana. Thus the aim of this study was to determine the possible sand fly vector species in Ghana, as well as their human-feeding behavior, from the time of the first reported outbreak of CL in the country.

methodsSand flies were collected from randomly selected houses in three communities. They were identified and used for blood meal source identification and the detection of Leishmania infection using molecular methods. 

resultsA total of 1051 female sand flies were morphologically identified, of which Sergentomyia africana africana (29%) was the predominant species. Among the 275 female sand flies that had blood-fed, the identified blood meal sources included chicken (33.8%) and goat (12.4%); the percentage of human blood meals was 32%. Single-source and mixed-source blood meals were identified in Sergentomyia africana africana (11.6%), Sergentomyia ingrami (14.9%) and Sergentomyia simillima (20%), with S. simillima having the highest proportion of blood meals that included human blood (14.6%). Using molecular methods, unfed sand flies and identified human-feeding species were examined for the presence of Leishmania DNA. Pool screening analysis revealed three pools of S. ingrami positive for Leishmania major DNA, with an infection rate of 1.27% (95% confidence interval 2.467-3.647).

conclusionsThe findings suggest that some Sergentomyia species may be involved in the transmission of cutaneous leishmaniasis in Ghana. However, the role of S. ingrami as a vector of leishmaniasis in Ghana needs to be conclusively validated by isolating the parasite from this species and through experimental transmission studies.

Indexed as

Leishmania majorLeishmaniasisLeishmaniasis, CutaneousPhlebotomusPsychodidaeAnimalsDisease OutbreaksDNAFemaleGhanaHumansDNACutaneous leishmaniasisGhanaNeglected tropical diseasePhlebotomusSergentomyia

Identifiers

PMID37118766
PMCPMC10148561
OpenAlexW4367309580

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.