Evidence map›Paper›PMID 37118684›Full record

ArticleBMC psychiatry2023

Measurement invariance of the PHQ-9 and GAD-7 across males and females seeking treatment for common mental health disorders.

Rob Saunders, Delilah Moinian, Joshua Stott, Henry Delamain, Syed Ali Naqvi, Satwant Singh, Jon Wheatley, Stephen Pilling, Joshua E J Buckman

Registry-linked trialAbstract read
In one paragraph

Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06548022 (Rare Group Problem Management Plus), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06548022 nacompletednot on this mapstarted 2024, after this paper: background citation

Rare Group Problem Management Plus

TypeinterventionalSponsorChildren's National Research InstituteRan2024 to 2025Enrolled8ConditionsAnxiety, Depressive Symptoms, Post-traumatic Stress Disorder, Problems PsychosocialArmsRare Group Problem Management Plus
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Generalised anxiety disorder (GAD-7) in Ukrainian sample during wartime.Social psychiatry and psychiatric epidemiology · 2026
    Article
  3. Psychometric properties of the Chinese version of PROMIS-29 in patients receiving kidney replacement therapy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Article
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rob SaundersCORE Data Lab, Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational and Health Psychology, UCL, London, UK. r.saunders@ucl.ac.uk.
Delilah MoinianCORE Data Lab, Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational and Health Psychology, UCL, London, UK.
Joshua StottADAPT Lab, Research Department of Clinical, Educational and Health Psychology, UCL, London, UK.
Henry DelamainCORE Data Lab, Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational and Health Psychology, UCL, London, UK.
Syed Ali NaqviBarking & Dagenham and Havering IAPT Services, North East London NHS Foundation Trust, London, UK.
Satwant SinghWaltham Forest Talking Therapies, North East London NHS Foundation Trust, London, UK.
Jon WheatleyTalk Changes: City & Hackney IAPT Service, Homerton University Hospital NHS Foundation Trust, London, UK.
Stephen PillingCORE Data Lab, Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational and Health Psychology, UCL, London, UK.
Joshua E J BuckmanCORE Data Lab, Centre for Outcomes Research and Effectiveness (CORE), Research Department of Clinical, Educational and Health Psychology, UCL, London, UK.

Funding

Wellcome Trust 201292/Z/16/Z
6 · The paper itself

Abstract

backgroundThe nine-item Patient Health Questionnaire (PHQ-9) and the seven-item Generalised Anxiety Disorder scale (GAD-7) scales are routinely used in research and clinical practice. Whilst measurement invariance of these measures across gender has been demonstrated individually in general population studies and clinical samples, less is known about invariance of the distinct but correlated latent factors ('depression' and 'anxiety'). The current study assessed measurement invariance of these constructs across males and females seeking treatment for common mental health disorders.

methodsData were provided from eight psychological treatment services in London, England. Data from initial assessments with the services where individual items on the PHQ-9 and GAD-7 were available were included in analyses. Measurement invariance was explored across self-identified genders, with 'male' and 'female' categories available in the dataset. Sensitivity analyses were conducted using propensity score matching on sociodemographic and clinical variables.

resultsData were available for 165,872 patients (110,833 females, 55,039 males). There was evidence of measurement invariance between males and females in both the full sample and a propensity score matched sample (n = 46,249 in each group).

conclusionsMeasurement invariance of the correlated depression and anxiety factors of PHQ-9 and GAD-7 were indicated in this sample of individuals seeking psychological treatment for CMHDs. These results support the use of these measures in routine clinical practice for both males and females. This is of particular importance for assessing the prevalence of clinically significant levels of symptoms as well as comparing treatment outcomes across genders.

Indexed as

Mental HealthPatient Health QuestionnaireAnxietyAnxiety DisordersFemaleHumansMalePsychometricsTreatment OutcomeCommunity mental health servicesGAD-7GenderMeasurement invariancePHQ-9

Identifiers

PMID37118684
PMCPMC10148535

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.