ArticleNature aging2021
Distinct organization of adaptive immunity in the long-lived rodent Spalax galili.
Article in Nature aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- T Cell Thoughts.Immunological reviews · 2026Review
- Genomic signatures of subterranean lifestyle and ecological adaptation in Myospalax.BMC biology · 2025Article
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq.Frontiers in immunology · 2025Article
- Splice Variant ofGenes · 2024Article
- Invariant γδTCR natural killer-like effector T cells in the naked mole-rat.Nature communications · 2024Article
- Cross-species comparison illuminates the importance of iron homeostasis for splenic anti-immunosenescence.Aging cell · 2023Article
- Innate Immunity and Phenoptosis.Biochemistry. Biokhimiia · 2022Article
- Review
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Authors and funding
20 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A balanced immune response is a cornerstone of healthy aging. Here, we uncover distinctive features of the long-lived blind mole-rat (Spalax spp.) adaptive immune system, relative to humans and mice. The T-cell repertoire remains diverse throughout the Spalax lifespan, suggesting a paucity of large long-lived clones of effector-memory T cells. Expression of master transcription factors of T-cell differentiation, as well as checkpoint and cytotoxicity genes, remains low as Spalax ages. The thymus shrinks as in mice and humans, while interleukin-7 and interleukin-7 receptor expression remains high, potentially reflecting the sustained homeostasis of naive T cells. With aging, immunoglobulin hypermutation level does not increase and the immunoglobulin-M repertoire remains diverse, suggesting shorter B-cell memory and sustained homeostasis of innate-like B cells. The Spalax adaptive immune system thus appears biased towards sustained functional and receptor diversity over specialized, long-lived effector-memory clones-a unique organizational strategy that potentially underlies this animal's extraordinary longevity and healthy aging.
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