ArticleNature aging2023
Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes.
Article in Nature aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
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- Human RBM3 protein is prone to form neuronal aggregates opposed by the proteasome.Biology open · 2026Article
- Review
- NRF2-REGγ-ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The energy resistance principle.Cell metabolism · 2025Review
- Biomarkers of ageing of humans and non-human primates.Nature reviews. Molecular cell biology · 2025Review
- Evolutionary Analysis of Sex-Biased Gene Suggests Functional Conservation of Lifespan-Related Genes in Insecta.Biology · 2025Article
- The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation.Nature aging · 2025Article
- Long-term dietary allyl isothiocyanate, a TRPA1 agonist, ameliorates cardiac fibrosis and diastolic dysfunction in aged mice.GeroScience · 2025Article
- Modeling immunoglobulin light chain amyloidosis in Caenorhabditis elegans.Disease models & mechanisms · 2025Article
- Impact of seasons on elderly patients with esophageal squamous cell carcinoma following esophagectomy: a propensity score matching analysis.Discover oncology · 2025Article
- The Trade-Off Between the Increased Colony Nurturing Ability and the Decreased Lifespan of Worker Bees (Insects · 2025Article
- Promoting health and survival through lowered body temperature.Nature aging · 2025Review
- A Cold-Induced LEA3 Protein, DohD, Confers Cryoprotective Protection Against Low-Temperature Stress inInternational journal of molecular sciences · 2025Article
- Unraveling Molecular Targets for Neurodegenerative Diseases ThroughInternational journal of molecular sciences · 2025Review
- Article
- Resting Body Temperature and Long-Term Survival in Older Adults at a Mental Health Center: Cross-Sectional and Longitudinal Data.Journal of clinical medicine · 2025Article
- Mechanism of cold exposure delaying wound healing in mice.Journal of nanobiotechnology · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is a primary risk factor for neurodegenerative disorders that involve protein aggregation. Because lowering body temperature is one of the most effective mechanisms to extend longevity in both poikilotherms and homeotherms, a better understanding of cold-induced changes can lead to converging modifiers of pathological protein aggregation. Here, we find that cold temperature (15 °C) selectively induces the trypsin-like activity of the proteasome in Caenorhabditis elegans through PSME-3, the worm orthologue of human PA28γ/PSME3. This proteasome activator is required for cold-induced longevity and ameliorates age-related deficits in protein degradation. Moreover, cold-induced PA28γ/PSME-3 diminishes protein aggregation in C. elegans models of age-related diseases such as Huntington's and amyotrophic lateral sclerosis. Notably, exposure of human cells to moderate cold temperature (36 °C) also activates trypsin-like activity through PA28γ/PSME3, reducing disease-related protein aggregation and neurodegeneration. Together, our findings reveal a beneficial role of cold temperature that crosses evolutionary boundaries with potential implications for multi-disease prevention.
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