Evidence map›Paper›PMID 37118537›Full record

ArticleNature aging2022

Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1.

Guillermo Martínez Corrales, Mengjia Li, Tatiana Svermova, Alex Goncalves, Diana Voicu, Adam J Dobson, Tony D Southall, Nazif Alic

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PubMed Full text at PMC Publisher
In one paragraph

Article in Nature aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Guillermo Martínez Corrales *Institute of Healthy Ageing and the Research Department of Genetics, Evolution, and Environment, University College London, London, UK.ORCID 0000-0002-3923-5902
Mengjia Li *Institute of Healthy Ageing and the Research Department of Genetics, Evolution, and Environment, University College London, London, UK.
Tatiana SvermovaInstitute of Healthy Ageing and the Research Department of Genetics, Evolution, and Environment, University College London, London, UK.
Alex GoncalvesInstitute of Healthy Ageing and the Research Department of Genetics, Evolution, and Environment, University College London, London, UK.
Diana VoicuInstitute of Healthy Ageing and the Research Department of Genetics, Evolution, and Environment, University College London, London, UK.ORCID 0000-0001-7659-9759
Adam J DobsonSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Tony D SouthallDepartment of Life Sciences, Imperial College London, London, UK.
Nazif AlicInstitute of Healthy Ageing and the Research Department of Genetics, Evolution, and Environment, University College London, London, UK. n.alic@ucl.ac.uk.ORCID 0000-0003-0356-6600
University College London · GBImperial College London · GBMRC Unit for Lifelong Health and Ageing · GBUniversity of Glasgow · GB

Funding

RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/R014507/1RCUK | Medical Research Council (MRC) MR/S033939/1
6 · The paper itself

Abstract

A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal aging as animals encounter a multitude of diverse stimuli throughout their lifespan. Here we show that activating an evolutionarily conserved, longevity-promoting transcription factor, dFOXO, solely in early adulthood of female fruit flies is sufficient to improve their subsequent health and survival in midlife and late life. This youth-restricted dFOXO activation causes persistent changes to chromatin landscape in the fat body and requires chromatin remodelers such as the SWI/SNF and ISWI complexes to program health and longevity. Chromatin remodeling is accompanied by a long-lasting transcriptional program that is distinct from that observed during acute dFOXO activation and includes induction of Xbp1. We show that this later-life induction of Xbp1 is sufficient to curtail later-life mortality. Our study demonstrates that transcriptional memory can profoundly alter how animals age.

Indexed as

Chromatin Assembly and DisassemblyDrosophila ProteinsAnimalsChromatinDNA-Binding ProteinsDrosophilaFemaleGene Expression RegulationTranscription FactorsChromatinDNA-Binding ProteinsDrosophila ProteinsTranscription FactorsXbp1 protein, Drosophila

Identifiers

PMID37118537
PMCPMC7614430
OpenAlexW4311068384

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.