ReviewNature aging2022
The limitations of large-scale volunteer databases to address inequalities and global challenges in health and aging.
Review in Nature aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Stigma and health outcomes in multiple sclerosis: a systematic review.BMC neurology · 2024Pooled it
- Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Pooled it
- Time restricted eating and exercise training before and during pregnancy for people with increased risk of gestational diabetes: single centre randomised controlled trial (BEFORE THE BEGINNING).BMJ (Clinical research ed.) · 2025Trial
- NHS-Galleri trial: Enriched enrolment approaches and sociodemographic characteristics of enrolled participants.Clinical trials (London, England) · 2025Trial
- Gender-related facilitators and barriers to participation in research on aging using fuzzy cognitive mapping.Neurobiology of aging · 2026Article
- Men's perceptions of long-term health outcomes following fertility problems: a UK-based mixed-methods survey.Journal of assisted reproduction and genetics · 2026Article
- African ancestry-enriched variants in the GATM gene are associated with elevated serum creatinine levels.Genome medicine · 2026Article
- Article
- Methodological innovations in studying marginalized populations in research on neurodegeneration and ageing.Frontiers in aging neuroscience · 2026Review
- Phenome-wide analysis of genetically imputed neuroimaging phenotypes reveals associations with psychiatric traits in a multi-ancestry cohort.medRxiv : the preprint server for health sciences · 2025Article
- The nature of the relation between mental well-being and ill-being.Nature human behaviour · 2025Review
- Phenotyping Chronic Pain and Neuropathic Pain in Population Studies.European journal of pain (London, England) · 2025Review
- Medical risk factors, ApoE haplotype, and Alzheimer's disease: a large-scale analysis.The journal of prevention of Alzheimer's disease · 2025Article
- Health-related quality of life in the UK Biobank Experience of Pain follow-up study: a comparison with general population norms.American journal of epidemiology · 2025Article
- Myeloid neoplasms risks for germline DDX41 pathogenic variants carriers.European journal of human genetics : EJHG · 2025Article
- American Life in Realtime: Benchmark, publicly available person-generated health data for equity in precision health.PNAS nexus · 2025Article
- Outdoor physical activity, residential green spaces and the risk of dementia in the UK Biobank cohort.Communications medicine · 2025Article
- Sociodemographic, health-related, and clinical characteristics and their associations with mortality among All of Us participants compared with the United States general population.American journal of epidemiology · 2025Article
- The association of the planetary health diet with type 2 diabetes incidence and greenhouse gas emissions: Findings from the EPIC-Norfolk prospective cohort study.PLoS medicine · 2025Article
- Role of Nighttime Light in the Association Between Air Pollution Exposure and Cardiovascular Disease.Journal of the American Heart Association · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Large-scale volunteer databanks (LSVD) have emerged from the recognized value of cohorts, attracting substantial funding and promising great scientific value. A major focus is their size, with the implicit and sometimes explicit assumption that large size (thus power) creates generalizability. We contend that this is open to challenge. In the context of aging and age-related disease research, LSVD typically have limitations such as healthy volunteer, white ethnicity and high-education biases, and they omit early and late life stages critical for understanding aging. Their outputs are heavily focused on biomedical pathways of single chronic diseases. LSVD outputs increasingly dominate the funding and the publication landscapes. This Perspective discusses LSVD limitations and calls for more transparent reporting in LSVD research, as well as a greater reflection on the value of LSVD in relation to resources consumed. We invite funders and researchers to examine whether LSVD do actually contribute knowledge needed for our acute global health challenges including inequalities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.