Trial reportNature aging2023
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.
Erratum issuedOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Nature aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 186 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 1 pooled it
27.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
186 citing papers in PubMed, 1 synthesis or guideline pooled it, 173 citations in OpenAlex.
- Social determinants of health and epigenetic clocks: a systematic review and meta-analysis of 140 studies.Nature human behaviour · 2026Pooled it
- Effects of a randomized controlled trial of unconditional cash transfers on epigenetic measures of ageing and cognition in children and mothers.Nature human behaviour · 2026Trial
- Epigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations.GeroScience · 2026Trial
- Trial
- Semaglutide slows epigenetic aging in a randomized trial of HIV-associated lipohypertrophy.Nature communications · 2026Trial
- Trial
- Effects of daily multivitamin-multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial.Nature medicine · 2026Trial
- Trial
- Self-selected dietary intake and association with achieved caloric restriction in CALERIECritical reviews in food science and nutrition · 2026Trial
- Fasting Mimicking Diets Reverse Accelerated Biological Aging in Multiple Sclerosis.Annals of neurology · 2025Trial
- Epigenetic Age Acceleration and Cardiometabolic Biomarkers in Response to Weight-Loss Dietary Interventions Among Obese Individuals: The MACRO Trial.Aging cell · 2025Trial
- Trial
- Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial.Nature aging · 2025Trial
- The CALERIE Genomic Data Resource.Nature aging · 2025Trial
- The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial.BMC medicine · 2023Trial
- Epigenetic age deceleration reflects exercise-induced cardiorespiratory fitness improvements.GeroScience · 2026Article
- Caloric restriction attenuates age-related liver and kidney alterations in mice: Histological evidence.Histology and histopathology · 2026Article
- Intermittent fasting: Impact, mechanisms and cautions across medical and lifestyle domains.European journal of clinical nutrition · 2026Review
- Article
- DNA methylation variability provides a complementary epigenetic signature of aging heterogeneity: Findings from the Canadian Longitudinal Study on Aging and the Baltimore Longitudinal Study of Aging.bioRxiv : the preprint server for biology · 2026Article
126 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
22 authors at 10 institutions in 2 countries.
R Waziry *Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
C P Ryan *Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
D L CorcoranDepartment of Genetics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
K M HuffmanDuke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
M S KoborDepartment of Medical Genetics, Edwin S.H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
M KothariButler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
G H GrafButler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA.
V B KrausDuke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8173-8258
W E KrausDuke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0003-1930-9684
D T S LinDepartment of Medical Genetics, Edwin S.H. Leong Healthy Aging Program, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.
C F PieperCenter on Aging and Development, Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
M E RamakerDuke Molecular Physiology Institute and Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
M BhapkarDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA.
S K DasJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.
L FerrucciTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6273-1613
W J HastingsDepartment of Biobehavioral Health, Pennsylvania State University, State College, PA, USA.
M KebbePennington Biomedical Research Center, Baton Rouge, LA, USA.
D C ParkerDepartment of Medicine, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0001-8512-1044
S B RacetteProgram in Physical Therapy and Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6932-1887
I ShalevDepartment of Biobehavioral Health, Pennsylvania State University, State College, PA, USA.
B SchillingBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0001-9907-2749
D W BelskyButler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA. Daniel.Belsky@Columbia.edu.ORCID http://orcid.org/0000-0001-5463-2212
Duke University · USColumbia University · USPennsylvania State University · USUniversity of British Columbia · CABuck Institute for Research on Aging · USNational Institutes of Health · USPennington Biomedical Research Center · USTufts University · USUniversity of North Carolina at Chapel Hill · USWashington University in St. Louis · US
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MResource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6MIs mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5MLegacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and AgingR01AG071717 · NIA · TUFTS UNIVERSITY BOSTON · PI Sai Krupa Das, Susan Beth Racette · 2021 to 2026
$6.3MENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGYR33AG070455 · NIA · DUKE UNIVERSITY · PI KIM M. HUFFMAN, WILLIAM E KRAUS · 2021 to 2026
$4.0MQuantitative Proteomics to Develop Robust Senescence-Related Biomarkers for AgingU01AG060906 · NIA · BUCK INSTITUTE FOR RESEARCH ON AGING · PI SCHILLING, BIRGIT · 2018 to 2022
$4.0MGenetic analysis of the Dutch Hunger Winter Families Study to Boost Rigor and Robustness for Testing In-Utero Famine Effects on Aging-Related Health Conditions and Biological AgingR01AG066887 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BELSKY, DANIEL WALKER, LUMEY, L H · 2020 to 2024
$3.5MEpigenetic Mechanisms Promoting LongevityR01AG054840 · NIA · DUKE UNIVERSITY · PI KRAUS, VIRGINIA · 2018 to 2022
$3.4MElucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research NetworkU24AG066528 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI DRURY, STACY SCHMIDT · 2019 to 2023
$3.0MLong-term multi-omics follow-up of the CALERIE Trial to generate new knowledge for geroscienceR01AG061378 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Daniel Walker Belsky · 2019 to 2026
$2.9MTelomere length analysis in the CALERIE trialR03AG071549 · NIA · PENNSYLVANIA STATE UNIVERSITY, THE · PI SHALEV, IDAN · 2022 to 2023
$158kNIA NIH HHS P30 AG028716NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG054840NIA NIH HHS R01 AG061378NIA NIH HHS R01 AG066887NIA NIH HHS R01 AG071717NIA NIH HHS R03 AG071549NIA NIH HHS R33 AG070455NIA NIH HHS U01 AG060906NIA NIH HHS U24 AG066528NIDDK NIH HHS P30 DK056341
Abstract
The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan
Indexed as
Caloric RestrictionDNA MethylationAdultAgingEnergy IntakeHumansLongevity
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.