ArticleNature aging2022
The brain structure and genetic mechanisms underlying the nonlinear association between sleep duration, cognition and mental health.
Article in Nature aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 118 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
118 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of sleep duration and risk of mental disorder: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Low-dose dexmedetomidine improves postoperative sleep and pain in gynecological surgery: a randomized trial.Frontiers in pharmacology · 2026Trial
- Measuring the Impacts of Urbanicity and Different Exposome Factors on Human Brain through Exposure Network Mapping.Neuroscience bulletin · 2026Article
- Accelerometer-derived real-world sleep stages and risk of incident diseases: A UK Biobank cohort study and phenome-wide association analysis.PLoS medicine · 2026Article
- Optimal 24-Hour Sleep Duration and Depression Risk in Chinese Middle-Aged and Elderly: A Machine Learning and RCS Analysis of Nonlinear Associations.The Psychiatric quarterly · 2026Article
- Article
- The role of psychopharmacology and cognitive neuroscience in understanding the brain in the treatment of psychiatric disorders and neurological diseases for the benefit of society.Journal of psychopharmacology (Oxford, England) · 2026Article
- Elevating sleep to a global health priority: The One Sleep Health framework.Cell reports. Medicine · 2026Review
- Prediction of cognitive performance by demographics, sleep, and brain morphometry: machine learning findings from ENIGMA-Sleep Working Group.Research square · 2026Article
- Research on gut microbiota and metabolic characteristics in patients with sleep disorders after ischemic stroke.Metabolic brain disease · 2026Article
- Multi-organ imaging and genetics show the impact of sleep patterns on the human brain and body.Communications medicine · 2026Article
- Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants.Nature communications · 2026Article
- Joint associations of multiple healthy lifestyles with the risk of cardiovascular disease: a prospective cohort study of UK Biobank.European journal of public health · 2026Article
- Joint effects of sleep behaviors and physical activity on brain structure and cognitive function.Fundamental research · 2026Article
- Sleep duration and cognitive function in middle-aged and older adults: a multinational study in China, England, and India.BMC public health · 2026Article
- Sleep disturbances and Alzheimer's disease: a multiscale approach from exposome to neurobiology and precision medicine.GeroScience · 2026Review
- The association of sleep duration on weekdays with rheumatoid arthritis: a cross-sectional study from NHANES.BMC public health · 2026Article
- Sleep duration trajectories and cognitive impairment among elderly: a 13-year cohort study in China.BMC geriatrics · 2026Article
- Chain mediating effect of somatic pain and sleep duration between chronic disease count and depressive symptoms in older adults.Frontiers in psychiatry · 2026Article
- Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
Sleep duration, psychiatric disorders and dementias are closely interconnected in older adults. However, the underlying genetic mechanisms and brain structural changes are unknown. Using data from the UK Biobank for participants primarily of European ancestry aged 38-73 years, including 94% white people, we identified a nonlinear association between sleep, with approximately 7 h as the optimal sleep duration, and genetic and cognitive factors, brain structure, and mental health as key measures. The brain regions most significantly underlying this interconnection included the precentral cortex, the lateral orbitofrontal cortex and the hippocampus. Longitudinal analysis revealed that both insufficient and excessive sleep duration were significantly associated with a decline in cognition on follow up. Furthermore, mediation analysis and structural equation modeling identified a unified model incorporating polygenic risk score (PRS), sleep, brain structure, cognition and mental health. This indicates that possible genetic mechanisms and brain structural changes may underlie the nonlinear relationship between sleep duration and cognition and mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.