Evidence map›Paper›PMID 37118005›Full record

ArticleNature aging2021

Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging.

Emma S Chambers, Milica Vukmanovic-Stejic, Barbara B Shih, Hugh Trahair, Priya Subramanian, Oliver P Devine, James Glanville, Derek Gilroy, Malcolm H A Rustin, Tom C Freeman and 2 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 86 citations in OpenAlex.

  1. Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
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  5. Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Emma S Chambers *Division of Infection and Immunity, University College London, London, UK.ORCID 0000-0003-0990-8835
Milica Vukmanovic-Stejic *Division of Infection and Immunity, University College London, London, UK.
Barbara B ShihThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.
Hugh TrahairDivision of Infection and Immunity, University College London, London, UK.ORCID 0000-0002-9752-3558
Priya SubramanianDivision of Infection and Immunity, University College London, London, UK.
Oliver P DevineDivision of Infection and Immunity, University College London, London, UK.
James GlanvilleDivision of Medicine, University College London, London, UK.ORCID 0000-0002-5653-3960
Derek GilroyDivision of Medicine, University College London, London, UK.
Malcolm H A RustinDepartment of Dermatology, Royal Free Hospital, London, UK.
Tom C FreemanThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.
Neil A MabbottThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK.ORCID 0000-0001-7395-1796
Arne N AkbarDivision of Infection and Immunity, University College London, London, UK. a.akbar@ucl.ac.uk.ORCID 0000-0002-3763-9380
University College London · GBRoslin Institute · GBInstitute of Infection and Immunity · CAQueen Mary University of London · GBThe Royal Free Hospital · GB

Funding

Biotechnology and Biological Sciences Research Council BBS/E/D/20002173Medical Research Council G0901102Medical Research Council MR/M003833/1Medical Research Council MR/T030534/1
6 · The paper itself

Abstract

We have previously shown that healthy older adults exhibit reduced cutaneous immune responses during a varicella zoster virus (VZV) antigen challenge that correlated with a nonspecific inflammatory response to the injection itself. Here we found that needle damage during intradermal injections in older adults led to an increase in the number of cutaneous senescent fibroblasts expressing CCL2, resulting in the local recruitment of inflammatory monocytes. These infiltrating monocytes secreted prostaglandin E2, which inhibited resident memory T cell activation and proliferation. Pretreatment of older participants with a p38 mitogen-activated protein kinase inhibitor in vivo decreased CCL2 expression and inhibited monocyte recruitment and secretion of prostaglandin E2. This coincided with an increased response to VZV antigen challenge in the skin. Our results point to a series of molecular and cellular mechanisms that link cellular senescence, tissue damage, excessive inflammation and reduced immune responsiveness in human skin and demonstrate that tissue-specific immunity can be restored in older adults by short-term inhibition of inflammatory responses.

Indexed as

DinoprostoneMonocytesAgedAgingFibroblastsHerpesvirus 3, HumanHumansLymphocyte ActivationDinoprostone

Identifiers

PMID37118005
OpenAlexW3118863695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.