Evidence map›Paper›PMID 37117817›Full record

ReviewNature reviews. Chemistry2023

Targeting the human gut microbiome with small-molecule inhibitors.

Amelia Y M Woo, Miguel A Aguilar Ramos, Rohan Narayan, Khyle C Richards-Corke, Michelle L Wang, Walter J Sandoval-Espinola, Emily P Balskus

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Another renaissance for bile acid gastrointestinal microbiology.Nature reviews. Gastroenterology & hepatology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Amelia Y M WooHarvard University, Department of Chemistry and Chemical Biology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8338-7578
Miguel A Aguilar RamosHarvard University, Department of Chemistry and Chemical Biology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2537-8371
Rohan NarayanHarvard University, Department of Chemistry and Chemical Biology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8783-7636
Khyle C Richards-CorkeHarvard University, Department of Chemistry and Chemical Biology, Cambridge, MA, USA.
Michelle L WangHarvard University, Department of Chemistry and Chemical Biology, Cambridge, MA, USA.
Walter J Sandoval-EspinolaHarvard University, Department of Chemistry and Chemical Biology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9107-6144
Emily P BalskusHarvard University, Department of Chemistry and Chemical Biology, Cambridge, MA, USA. balskus@chemistry.harvard.edu.ORCID http://orcid.org/0000-0001-5985-5714

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human gut microbiome is a complex microbial community that is strongly linked to both host health and disease. However, the detailed molecular mechanisms underlying the effects of these microorganisms on host biology remain largely uncharacterized. The development of non-lethal, small-molecule inhibitors that target specific gut microbial activities enables a powerful but underutilized approach to studying the gut microbiome and a promising therapeutic strategy. In this Review, we will discuss the challenges of studying this microbial community, the historic use of small-molecule inhibitors in microbial ecology, and recent applications of this strategy. We also discuss the evidence suggesting that host-targeted drugs can affect the growth and metabolism of gut microbes. Finally, we address the issues of developing and implementing microbiome-targeted small-molecule inhibitors and define important future directions for this research.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaHumans

Identifiers

PMID37117817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.