ReviewNature reviews. Chemistry2023
Design principles of the use of alkynes in radical cascades.
Review in Nature reviews. Chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Enantioselective Vinyl Radical Addition to Aldehydes via Dual Chromium Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Discovery of a Structurally Distinct Acetylenase in the Biosynthesis of Mangotoxin.Journal of the American Chemical Society · 2026Article
- One-Pot Transition-Metal-Free Methods for the Synthesis of All Three Bonds of the Alkyne's Triple Bond.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Radical docking-migration: a powerful strategy for difunctionalization of alkenes and alkynes.Chemical science · 2026Review
- Photocyclization of Alkenes and Arenes: Penetrating Through Aromatic Armor with the Help of Excited State Antiaromaticity.Chemistry (Basel, Switzerland) · 2025Article
- General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines.Nature communications · 2025Article
- Carbosulfonylation of Alkynes: A Direct Conversion of sp-C to spOrganic letters · 2024Article
- C3 Selective chalcogenation and fluorination of pyridine using classic Zincke imine intermediates.Nature communications · 2024Article
- E-Selective Radical Difunctionalization of Unactivated Alkynes: Preparation of Functionalized Allyl Alcohols from Aliphatic Alkynes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Visible Light-Mediated Heterodifunctionalization of Alkynylazobenzenes for 2Organic letters · 2024Article
- Recent advances in the application of alkynes in multicomponent reactions.RSC advances · 2024Review
- Photocatalytic Boryl Radicals Triggered Sequential B─N/C─N Bond Formation to Assemble Boron-Handled Pyrazoles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Photoredox-Catalyzed Divergent Radical Cascade Annulations of 1,6-Enynes via PyridineOrganic letters · 2023Article
- An Unusual Rearrangement of Pyrazole Nitrene and Coarctate Ring-Opening/Recyclization Cascade: Formal CH-Acetoxylation and Azide/Amine Conversion without External Oxidants and Reductants.Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the simplest organic functional groups, the alkyne, offers a broad canvas for the design of cascade transformations in which up to three new bonds can be added to each of the two sterically unencumbered, energy-rich carbon atoms. However, kinetic protection provided by strong π-orbital overlap makes the design of new alkyne transformations a stereoelectronic puzzle, especially on multifunctional substrates. This Review describes the electronic properties contributing to the unique utility of alkynes in radical cascades. We describe how to control the selectivity of alkyne activation by various methods, from dynamic covalent chemistry with kinetic self-sorting to disappearing directing groups. Additionally, we demonstrate how the selection of reactive intermediates directly influences the propagation and termination of the cascade. Diverging from a common departure point, a carefully planned reaction route can allow access to a variety of products.
Indexed as
Identifiers
37117812What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.