ReviewNature reviews. Chemistry2023
Detection and analysis of chiral molecules as disease biomarkers.
Review in Nature reviews. Chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 192 citations in OpenAlex.
- Article
- [Recent progress in constructions and applications of chiral porous framework-based chromatographic stationary phases].Se pu = Chinese journal of chromatography · 2026Article
- Cobalt-Catalyzed Reductive Asymmetric Dimerization of 1,3-Enynes: Rapid Synthesis of Enantioenriched Skipped 1,3,6-Trienes.Angewandte Chemie (International ed. in English) · 2026Article
- Shaping light in 3D for direct asymmetric photochemistry: a 1000-fold enantioselectivity enhancement.Nature communications · 2026Article
- Emergence of Chiral Defective Pores Through Chiral Linker Exchange in Nonchiral MOFs for Enantioselective Recognition.Angewandte Chemie (International ed. in English) · 2026Article
- Mass Spectrometry in Chiral Analysis and Synthesis.Chirality · 2026Article
- Application of Analytical Techniques to Chiral Amino Acid Profiling in Clinical Samples: Bridging Chemistry and Disease Research.Chirality · 2026Review
- Chiral Micellar Assemblies for Circularly Polarized Luminescence Amplification, Dye Encapsulation, and Multilevel Information Encryption.Angewandte Chemie (International ed. in English) · 2026Article
- Capillary Integrated SERS System Inspired by Bee-Hive Bionics: Enabling Dynamic Multi-Component Detection of Trace Biomolecules.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Liposome-cyclodextrin synergistic system for enhanced chiral separation of Fmoc-amino acid enantiomers in capillary electrophoresis.Mikrochimica acta · 2026Article
- Longitudinal fecal amino acid profiles in extremely preterm infants: early-life determinants and associations with late-onset sepsis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Enhanced chiral discrimination in mass spectrometry with orbital angular momentum beams.Science advances · 2026Article
- Biomolecular and cellular chirality: Novel diagnostic perspectives for diseases.APL bioengineering · 2026Review
- Decoding chirality at the nanoscale with momentum-space polarimetry.Light, science & applications · 2026Article
- Chiral Ligand-Protected Gold Nanoclusters as Biosensors for Small Chiral Biomolecules: A Computational Study.ACS nano · 2026Article
- Trash or treasure? Unlocking dark matter of enantiomeric natural products in innovative drugs discovery for potent angiogenesis inhibitors.Marine life science & technology · 2026Article
- Contact Electrification-Based Enantioselective Recognition of Chiral Amino Acids through Stereospecific Interfacial Electron Transfer.Journal of the American Chemical Society · 2026Article
- Impact of Thymidine Loop Modifications on Telomeric G-Quadruplex Catalytic Systems for Asymmetric Sulfoxidation.Molecules (Basel, Switzerland) · 2026Article
- Quantum-elevated chiral discrimination for biomolecules.Science advances · 2026Article
- Rapid enantioselective fluorescence recognition and chiral separation of free amino acids.Nature communications · 2026Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The chirality of small metabolic molecules is important in controlling physiological processes and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules in biofluids and tissues occur in many diseases, including cancers and kidney and brain diseases. Thus, chiral small molecules are promising biomarkers for disease diagnosis, prognosis, adverse drug-effect monitoring, pharmacodynamic studies and personalized medicine. However, it remains difficult to achieve cost-effective and reliable analysis of small chiral molecules in clinical procedures, in part owing to their large variety and low concentration. In this Review, we describe current and emerging techniques that detect and quantify small-molecule enantiomers and their biological importance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.