ReviewNature aging2022
A complex systems approach to aging biology.
Review in Nature aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 2 syntheses or guidelines pooled it, 190 citations in OpenAlex.
- Retinal biomarkers for early Alzheimer's detection: a systematic review of optical coherence tomography (OCT) findings.BMJ open ophthalmology · 2026Pooled it
- Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle.Aging cell · 2024Pooled it
- Histological aging signatures for monitoring tissue-specific aging and disease.Nature medicine · 2026Article
- Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight.Experimental physiology · 2026Review
- Age and loneliness relate to reduced trust learning and alterations in amygdala function.iScience · 2026Article
- Using the Stressor-System-Resilience Resources-Outcomes (SSRO) scaffold to clarify the core components of resilience research in medicine.Communications medicine · 2026Review
- Exercise-Mediated Modulation of the NLRP3 Inflammasome in Aging and Neurodegenerative Diseases: Mechanisms, Microglial Crosstalk, and Translational Perspectives.Molecular neurobiology · 2026Review
- Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026Review
- Biological Aging, Immune Phenotypes, and Susceptibility to COVID-19 and Sepsis: A Mendelian Randomization Study.Virus research · 2026Article
- Positioning TERT at the apex of aging.Nature aging · 2026Review
- Embracing complexity in transfusion research.Vox sanguinis · 2026Review
- Network-driven discovery of repurposable drugs targeting hallmarks of aging.Nature aging · 2026Article
- Thermophysiological BioEnergy Index as a Biomarker of Biological Ageing: A Large-Scale Microwave Radiometry Study.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Global characterization of extrachromosomal circular DNA in cerebrospinal fluid of lung adenocarcinoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Data and knowledge-driven imaging biomarkers for lumbar aging and degenerative risk stratification monitoring.NPJ digital medicine · 2026Article
- Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents.Brain and behavior · 2026Review
- Dynamics of the end-of-life phase explained by the saturating removal model.bioRxiv : the preprint server for biology · 2026Article
- Bat-Inspired Longevity: Immune Damage Management and Nutritional Modulation for Healthy Aging.International journal of molecular sciences · 2026Review
- Healthcare utilisation patterns among frail individuals aged 50+ years: results from the Lolland-Falster Population Study (LOFUS).BMJ open · 2026Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 10 institutions in 4 countries.
Funding
Abstract
Having made substantial progress understanding molecules, cells, genes and pathways, aging biology research is now moving toward integration of these parts, attempting to understand how their joint dynamics may contribute to aging. Such a shift of perspective requires the adoption of a formal complex systems framework, a transition being facilitated by large-scale data collection and new analytical tools. Here, we provide a theoretical framework to orient researchers around key concepts for this transition, notably emergence, interaction networks and resilience. Drawing on evolutionary theory, network theory and principles of homeostasis, we propose that organismal function is accomplished by the integration of regulatory mechanisms at multiple hierarchical scales, and that the disruption of this ensemble causes the phenotypic and functional manifestations of aging. We present key examples at scales ranging from sub-organismal biology to clinical geriatrics, outlining how this approach can potentially enrich our understanding of aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.