Evidence map›Paper›PMID 37117767›Full record

ArticleNature aging2021

Microbiota from young mice counteracts selective age-associated behavioral deficits.

Marcus Boehme, Katherine E Guzzetta, Thomaz F S Bastiaanssen, Marcel van de Wouw, Gerard M Moloney, Andreu Gual-Grau, Simon Spichak, Loreto Olavarría-Ramírez, Patrick Fitzgerald, Enrique Morillas and 15 more

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Nature aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers.

0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

168 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. The Hallmarks of Aging: From Molecular Mechanisms to Clinical Translation.International journal of molecular sciences · 2026
    Review
  5. Article
  6. Evolutionary genetics of ageing.Nature reviews. Genetics · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. The Critical Period Microbiota Shape Brain Plasticity.bioRxiv : the preprint server for biology · 2026
    Article
  16. Review
  17. Review
  18. Review
  19. Review
  20. Review

108 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Marcus Boehme *APC Microbiome Ireland, University College Cork, Cork, Ireland.
Katherine E Guzzetta *APC Microbiome Ireland, University College Cork, Cork, Ireland.
Thomaz F S Bastiaanssen *APC Microbiome Ireland, University College Cork, Cork, Ireland.
Marcel van de WouwAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-2607-314X
Gerard M MoloneyAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-3672-1390
Andreu Gual-GrauAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-8901-3582
Simon SpichakAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Loreto Olavarría-RamírezAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Patrick FitzgeraldAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Enrique MorillasAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Nathaniel L RitzAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Minal JaggarAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Caitlin S M CowanAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-2959-1380
Fiona CrispieAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Francisco DonosoAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Evelyn HalitzkiAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Marta C NetoAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-4699-7657
Marzia SichettiAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Anna V GolubevaAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Rachel S FitzgeraldAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Marcus J ClaessonAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-5712-0623
Paul D CotterAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-5465-9068
Olivia F O'LearyAPC Microbiome Ireland, University College Cork, Cork, Ireland.
Timothy G DinanAPC Microbiome Ireland, University College Cork, Cork, Ireland.ORCID 0000-0002-2316-7220
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland. j.cryan@ucc.ie.ORCID 0000-0001-5887-2723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However, there is limited evidence for a mechanistic role of the gut microbiota in brain health and neuroimmunity during aging processes. Therefore, we conducted fecal microbiota transplantation from either young (3-4 months) or old (19-20 months) donor mice into aged recipient mice (19-20 months). Transplant of a microbiota from young donors reversed aging-associated differences in peripheral and brain immunity, as well as the hippocampal metabolome and transcriptome of aging recipient mice. Finally, the young donor-derived microbiota attenuated selective age-associated impairments in cognitive behavior when transplanted into an aged host. Our results reveal that the microbiome may be a suitable therapeutic target to promote healthy aging.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAgingAnimalsBrainFecal Microbiota TransplantationMice

Identifiers

PMID37117767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.