Evidence map›Paper›PMID 37117690›Full record

ArticleScientific reports2023

Peptide microarray-based identification of dormancy-associated Mycobacterium tuberculosis antigens inducing immune responses among latent tuberculosis infection individuals in Thailand.

Jariya Hanthamrongwit, Panicha Aruvornlop, Chutiphon Saelee, Nattiya Wanta, Passarun Poneksawat, Phyu Thwe Soe, Soe Paing Kyaw, Prasong Khaenam, Saradee Warit, Davide Valentini and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Immunodominant Tuberculosis Antigens Recognized by Human CD4Cold Spring Harbor perspectives in medicine · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Jariya Hanthamrongwit *Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Panicha Aruvornlop *Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Chutiphon SaeleeDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Nattiya WantaCenter of Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Passarun PoneksawatCenter of Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Phyu Thwe SoeDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Soe Paing KyawClinical Pathology Laboratory, (1000) Bedded General Hospital, Nay Pyi Taw, 15011, Myanmar.
Prasong KhaenamCenter of Standardization and Product Validation, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Saradee WaritIndustrial Tuberculosis Team, Industrial Medical Molecular Biotechnology Research Group, BIOTEC, National Science and Technology Development Agency, Thailand Science Park, Pathum Thani, 12120, Thailand.
Davide ValentiniDepartment of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Surakameth MahasirimongkolMedical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Panadda DhepaksonMedical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Sakulrat SoonthornchartrawatMedical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Patchanee ChootongDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand.
Chaniya LeepiyasakulchaiDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, 10700, Thailand. chaniya.lee@mahidol.edu.
Mahidol University · THDepartment of Medical Sciences · THKarolinska Institutet · SELivestock Breeding and Veterinary Department · MMMinistry of Public Health · THNational Center for Genetic Engineering and Biotechnology · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multi-stage tuberculosis (TB) vaccines composed of active- and dormancy-associated antigens are promising to trigger the immune protection against all TB stages. However, scientists are still in quest of the suitable vaccine candidates. In this study, we identified the potential targets for this vaccine in a high TB burden country, Thailand. Peptide microarray was applied to gauge IgA and IgG antibodies specific to 16,730 linear epitopes of 52 dormancy-associated Mycobacterium tuberculosis (M. tb) proteins in three study groups: active tuberculosis (ATB), latent tuberculosis infection (LTBI) and endemic healthy control (EHC). Preferential IgA recognition against epitopes of dormancy-associated proteins was identified in LTBI group. Validation of these findings revealed that LTBI subjects exhibited the greater levels of Rv2659c- and Rv1738-specific IgA than those of household contacts, but less than did ATB subjects. Frequencies of IFNγ-producing CD4

Indexed as

Latent TuberculosisMycobacterium tuberculosisTuberculosisAntigens, BacterialCD8-Positive T-LymphocytesHumansImmunity, CellularImmunoglobulin APeptidesThailandAntigens, BacterialImmunoglobulin AMycobacterium tuberculosis antigensPeptides

Identifiers

PMID37117690
PMCPMC10141872
OpenAlexW4367297763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.