ReviewNature reviews. Chemistry2021
The application of modern reactions in large-scale synthesis.
Review in Nature reviews. Chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Compartmentalized Liquid Microenvironments of Pickering Emulsion Droplets for Continuous-Flow Catalysis.JACS Au · 2026Review
- Spin-State Dichotomy of On-Cycle Cobalt(II) Organometallics Informs Polar Cobalt(0/II) Versus Radical Cobalt(I/II/III) Cross-Coupling Mechanisms.Angewandte Chemie (International ed. in English) · 2026Article
- Sustainable Synthesis of 4,7-Dihydro-4,7-ethano-2H-isoindoles-Key Building Blocks to Benzoporphyrins.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Synergistic Catalysis: Integrating Acids, Metals, and Light in Nature-Inspired Asymmetric Multicomponent Synthesis.Topics in current chemistry (Cham) · 2026Review
- Tea-residue-derived carbon nanomaterials for adsorption-degradation coupling: mechanistic insights into pollutant removal and sustainability challenges.RSC advances · 2026Review
- Transformational Catalytic Innovation Supports COChemistryOpen · 2026Review
- Staged Diversity-Constrained Machine Learning for High-Dimensional Reaction Condition Optimization.Angewandte Chemie (International ed. in English) · 2026Article
- Indium phosphide quantum dots: advanced synthesis, surface engineering, and biomedical applications in imaging, sensing, and therapy.RSC advances · 2026Review
- Reductive radical chain initiation through the thermal generation of carbon dioxide radical anion.Nature synthesis · 2026Article
- Use of Electron-Transfer Mediators to Access Higher Electrochemical Current Densities in Ni-Catalyzed Cross-Electrophile Coupling.Journal of the American Chemical Society · 2025Article
- Simultaneous conversion of dialkyl phosphites to dialkyl phosphoric acids and SeORSC advances · 2025Article
- Maillard Reaction-Derived Carbon Nanodots: Food-Origin Nanomaterials with Emerging Functional and Biomedical Potential.Pharmaceutics · 2025Review
- Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology.Journal of the American Chemical Society · 2025Review
- Design, structure, and application of conductive polymer hybrid materials: a comprehensive review of classification, fabrication, and multifunctionality.RSC advances · 2025Review
- Flow-to-Flow Technology: Amide Formation in the Absence of Traditional Coupling Reagents Using DPDTC.ACS sustainable chemistry & engineering · 2025Article
- Chemical Process Development in the Pharmaceutical Industry in Europe-Insights and Perspectives from Industry Scientists.Angewandte Chemie (International ed. in English) · 2025Review
- Scaling Up Gas-Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source.Organic process research & development · 2025Article
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- Modified Working Electrodes for Organic Electrosynthesis.ACS organic & inorganic Au · 2024Review
- An automatic end-to-end chemical synthesis development platform powered by large language models.Nature communications · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past decade, the field of organic synthesis has witnessed tremendous advancements in the areas of photoredox catalysis, electrochemistry, C-H activation, reductive coupling and flow chemistry. While these methods and technologies offer many strategic advantages in streamlining syntheses, their application on the process scale is complicated by several factors. In this Review, we discuss the challenges that arise when these reaction classes and/or flow chemistry technology are taken from a research laboratory operating at the milligram scale to a reactor capable of producing kilograms of product. We discuss how these challenges have been overcome through chemical and engineering solutions. Specifically, this Review will highlight key examples that have led to the production of multi-hundred-gram to kilogram quantities of active pharmaceutical ingredients or their intermediates and will provide insight on the scaling-up process to those developing new technologies and reactions.
Identifiers
37117583What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.