ReviewNature reviews. Chemistry2021
The many flavours of mechanochemistry and its plausible conceptual underpinnings.
Review in Nature reviews. Chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
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Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 317 citations in OpenAlex.
- Shaking Things from the Ground-Up: A Systematic Overview of the Mechanochemistry of Hard and High-Melting Inorganic Materials.Molecules (Basel, Switzerland) · 2023Pooled it
- Force-modulated and strain-dependent stereoselectivity of copper-catalyzed reductive coupling.Chemical science · 2026Article
- Controlling Solid-State Mechanochemical Pathways in Triarylmethane Mechanophores via Molecular and Matrix Design.Macromolecules · 2026Article
- Reinventing the Corey-Fuchs Reaction under Ball Milling Conditions: A Mechanochemical Pathway to Bromoalkynes.ACS omega · 2026Article
- DYNO-MILL-Assisted Mechanochemistry: Design of Experiments Optimization for Sustainable Synthesis of Pyrrolo[3,4-c]pyrazoles.ChemSusChem · 2026Article
- Force-Accelerated Autocatalysis in a Knoevenagel Condensation Reaction during Ball Milling.Journal of the American Chemical Society · 2026Article
- Tailored Nanogel Network Topology Enables Clinical Ultrasound-Induced Mechanochemical Activation for In Vivo Therapy.Angewandte Chemie (International ed. in English) · 2026Article
- Mechanochemical Dehydrogenative Phenochalcogenazination: A Pronounced Water Effect.ChemSusChem · 2026Article
- Modeling Targeted Mechanochemistry in Polymeric Solids.Chemical reviews · 2026Review
- Mechanochemical Methods for Amide Bond Formation.Chemical reviews · 2026Review
- The mechanochemical activation of a pyrimidine dimer.Chemical science · 2026Article
- Mechanochemical and machine-intelligent design of programmable materials: From molecular interactions to macroscale functionality.Materials today. Bio · 2026Review
- A reflection on synthesis by extrusion ten years on: achievements, challenges and opportunities for solvent-free, sustainable, continuous chemical manufacturing.Chemical science · 2026Article
- Size-Dependent Ultrasound Activation of Thrombin Catalytic Activity by Mechano-Nanoswitches.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Mechanochemical Nitrous Oxide Decomposition.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Ga-Based Liquid Metal Catalyst for Mechano-Assisted Carbon-Carbon Coupling Reaction.Research (Washington, D.C.) · 2026Article
- Mechanochemical-Aging Synthesis of Bismuth Oxide Nanosheets for Photocatalysis.ACS materials Au · 2025Article
- Review
- Direct observation of electrostatic charging in 3D printing.Nature communications · 2025Article
- Advances in Mechanochemical Methods for One-Pot Multistep Organic Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanochemistry describes diverse phenomena in which mechanical load affects chemical reactivity. The fuzziness of this definition means that it includes processes as seemingly disparate as motor protein function, organic synthesis in a ball mill, reactions at a propagating crack, chemical actuation, and polymer fragmentation in fast solvent flows and in mastication. In chemistry, the rate of a reaction in a flask does not depend on how fast the flask moves in space. In mechanochemistry, the rate at which a material is deformed affects which and how many bonds break. In other words, in some manifestations of mechanochemistry, macroscopic motion powers otherwise endergonic reactions. In others, spontaneous chemical reactions drive mechanical motion. Neither requires thermal or electrostatic gradients. Distinct manifestations of mechanochemistry are conventionally treated as being conceptually independent, which slows the field in its transformation from being a collection of observations to a rigorous discipline. In this Review, we highlight observations suggesting that the unifying feature of mechanochemical phenomena may be the coupling between inertial motion at the microscale to macroscale and changes in chemical bonding enabled by transient build-up and relaxation of strains, from macroscopic to molecular. This dynamic coupling across multiple length scales and timescales also greatly complicates the conceptual understanding of mechanochemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.