Evidence map›Paper›PMID 37117225›Full record

ArticleScientific reports2023

Bi-glandular and persistent enterovirus infection and distinct changes of the pancreas in slowly progressive type 1 diabetes mellitus.

Tomoyasu Fukui, Tetsuro Kobayashi, Erika Jimbo, Kaoru Aida, Akira Shimada, Yoichi Oikawa, Yasumichi Mori, Takeshi Fujii, Rikako Koyama, Kazuhiko Kobayashi and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
46.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 149 citations in OpenAlex.

  1. Article
  2. Update on slowly progressive type 1 diabetes.Journal of diabetes investigation · 2025
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Tomoyasu FukuiDivision of Immunology and Molecular Medicine, Okinaka Memorial Institute for Medical Research, Tokyo, Japan.ORCID 0000-0002-8535-008X
Tetsuro KobayashiDivision of Immunology and Molecular Medicine, Okinaka Memorial Institute for Medical Research, Tokyo, Japan. tetsurou@yamanashi.ac.jp.ORCID 0000-0002-4364-2527
Erika JimboDivision of Immunology and Molecular Medicine, Okinaka Memorial Institute for Medical Research, Tokyo, Japan.
Kaoru AidaDepartment of Diabetes and Endocrinology, Kanoiwa Hospital, Yamanashi, Japan.
Akira ShimadaDepartment of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan.ORCID 0000-0002-3954-4983
Yoichi OikawaDepartment of Endocrinology and Diabetes, Saitama Medical University, Saitama, Japan.ORCID 0000-0003-1524-6751
Yasumichi MoriDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.
Takeshi FujiiDepartment of Pathology, Toranomon Hospital, Tokyo, Japan.ORCID 0000-0001-7237-1183
Rikako KoyamaDepartment of Gastroenterology, Toranomon Hospital, Tokyo, Japan.ORCID 0000-0002-5454-2660
Kazuhiko KobayashiGraduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-4101-2975
Akira TakeshitaDepartment of Endocrinology and Metabolism, Toranomon Hospital, Tokyo, Japan.ORCID 0000-0003-3685-9055
Soroku YagihashiDepartment of Exploratory Medicine on Nature, Life, and Man, Toho University of Medicine, Chiba, Japan.ORCID 0000-0003-4255-774X
Toranomon Hospital · JPSaitama Medical University · JPOkinaka Memorial Adult Disease Research Institute · JPShowa University · JPThe University of Tokyo · JPToho University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In slowly progressive type 1 diabetes mellitus (SPIDDM), the pancreas shows sustained islet inflammation, pancreatitis, pancreatic acinar cell metaplasia/dysplasia (ADM), and intraepithelial neoplasia (PanIN), a precancerous lesion. The mechanisms underlying these changes remain unclear. The presence of enterovirus (EV) encoded-capsid protein 1 (VP1) and -2A protease (2A

Indexed as

Diabetes Mellitus, Type 1EnterovirusEnterovirus InfectionsIslets of LangerhansPancreas, ExocrineAntigens, ViralHumansPancreasAntigens, Viral

Identifiers

PMID37117225
PMCPMC10147722
OpenAlexW4367297747

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.