ArticleTranslational psychiatry2023
Leveraging the microbiome to understand clinical heterogeneity in depression: findings from the T-RAD study.
Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- From association to causality: mechanistic pathways linking the gut microbiome to psychiatric disorders.Translational psychiatry · 2026Review
- Branched chain amino acid metabolism and microbiome in adolescents with obesity during weight loss therapy.The Journal of clinical investigation · 2026Observational
- Unraveling microbial signatures in the comorbidity of autoimmune diseases and depression.BMC microbiology · 2026Article
- Gut Microbiota Dysbiosis in Depression: Pathological Correlations, Molecular Pathways, and Therapeutic Interventions.International journal of molecular sciences · 2026Review
- A taxon-centered review of bacterial shifts in psychiatric disorders.Frontiers in psychiatry · 2026Review
- Microbiome driven modulation of neurotransmitters: implications for neurotransmission and mood disorders.Frontiers in microbiology · 2026Review
- The role of gut microbiome in the pathophysiology of PTSD, depression, and anxiety disorders.Gut microbes reports · 2026Review
- Effect of lysozyme supplementation on growth performance, immune status, antioxidant function and intestinal microbiota in broilers.Poultry science · 2025Article
- The Role of Gut-Brain Tryptophan Metabolism and Fatty Acid Peroxidation in the Effect of Sleep Deprivation on Anxiety and Depression in PCOS Mice.Molecular neurobiology · 2025Article
- Gender-Based Differences in Gut Microbiota Composition in Response to Anxiety and Stress in Shooting and Archery Athletes.Brain and behavior · 2025Article
- Nutrient-Synbiotic Complex Ameliorates LPS-Induced Depressive-Like Behavior via Modulation of Gut Microbiota and Tryptophan Metabolism in Mice.Food science & nutrition · 2025Article
- Medication use is associated with distinct microbial features in anxiety and depression.Molecular psychiatry · 2025Article
- The characteristics of anhedonia in depression: a review from a clinically oriented perspective.Translational psychiatry · 2025Review
- Nutritional Strategies in Major Depression Disorder: From Ketogenic Diet to Modulation of the Microbiota-Gut-Brain Axis.Molecular neurobiology · 2025Review
- The hidden genetic and microbial networks connecting neuropsychiatric and digestive disorders.Computational and structural biotechnology journal · 2025Article
- Quantifying hot topic dynamics in scientific literature: An information-theoretical approach.PloS one · 2025Article
- Association of Recreational Physical Activity with Gut Microbiota Diversity and Composition, and Symptom Burden in Crohn's Disease: A Cross-Sectional Study.Journal of inflammation research · 2025Article
- Gut microbiota, nutrients, and depression.Frontiers in nutrition · 2025Review
- Limosilactobacillus-related 3-OMDP as a potential therapeutic target for depression.Annals of medicine · 2024Article
- The gut-brain axis in depression: Are multi-omics showing the way?Cell reports. Medicine · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in the gut microbiome have been linked to a variety of mental illnesses including anxiety and depression. This study utilized advanced bioinformatics tools that integrated both the compositional and community nature of gut microbiota to investigate how gut microbiota influence clinical symptoms in a sample of participants with depression. Gut microbiota of 179 participants with major depressive disorder (MDD) in the Texas Resilience Against Depression (T-RAD) study were analyzed by 16S rRNA gene sequencing of stool samples. Severity of anxiety, depression, and anhedonia symptoms were assessed with General Anxiety Disorder - 7 item scale, Patient Health 9-item Questionnaire, and Dimensional Anhedonia Rating Scale, respectively. Using weighted correlation network analysis, a data-driven approach, three co-occurrence networks of bacterial taxa were identified. One of these co-occurrence networks was significantly associated with clinical features including depression and anxiety. The hub taxa associated with this co-occurrence module -one Ruminococcaceae family taxon, one Clostridiales vadinBB60 group family taxon, and one Christencenellaceae family taxon- were connected to several additional butyrate-producing bacteria suggesting that deficits in butyrate production may contribute to clinical symptoms. Therefore, by considering the community nature of the gut microbiome in a real world clinical sample, this study identified a gut microbial co-occurrence network that was significantly associated with clinical anxiety in a cohort of depressed individuals.
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